Impact of Iterative Reconstruction on the Diagnosis of Acute Pulmonary Embolism (PE) on Reduced-dose Chest CT Angiograms

Overview

Journal Eur Radiol

Specialty Radiology

Date 2015 Feb 1

PMID 25636413

Citations 13

Authors

Francois Pontana

Simon Henry

Alain Duhamel

Jean-Baptiste Faivre

Nunzia Tacelli

Julien Pagniez

Jacques Remy

Martine Remy-Jardin

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the impact of iterative reconstruction on the detectability of clots.

Methods And Materials: Fifty-three patients were enrolled in a study comparing reduced-dose and full-dose images, available from the same dual-source data set. From each acquisition, three series of images were generated: (1) full-dose images (from both tubes), reconstructed with filtered back projection (FBP) (group 1; standard of reference), (2) reduced-dose images (from tube A only; 60 % dose reduction) reconstructed with FBP (group 2) and iterative reconstruction (SAFIRE) (group 3).

Results: In group 1 (mean DLP: 264.6 mGy.cm), (1) PE was diagnosed in 8 patients (15 %) with 82 clots in the central (n = 5), segmental (n = 39) and subsegmental (n = 38) arteries and (2) mean level of noise was 30.56 ± 5.07. In group 2 (mean DLP: 105.8 mGy.cm), a significant increase in noise (44.56 ± 6.24; p < 0.0001) (1) hampered detection of PE in one patient and (2) altered detection of peripheral clots (12 false-negative and 2 false-positive results). In group 3, image noise was not significantly different from that in group 1 (p = 0.1525; effect size: 0.2683), with a similar detection of PE compared to group 1 (p = 1).

Conclusion: Reconstruction of reduced-dose images (60 % dose reduction) with SAFIRE provided image quality and diagnostic value comparable to those of full-dose FBP images.

Key Points: • Iterative reconstruction does not alter the detection of endoluminal clots. • Iterative reconstruction allows dose reduction in the context of acute PE. • Iterative reconstruction allows radiologists to approach the prospects of submilliSievert CT.

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Sinogram-Affirmed Iterative Reconstruction Negatively Impacts the Risk Category Based on Agatston Score: A Study Combining Coronary Calcium Score Measurement and Coronary CT Angiography.

Wang W, Zhao Y, Qi L, Zhou C, Lu M, Yang J Biomed Res Int. 2020; 2020:6909130.

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Computationally Efficient System Matrix Calculation Techniques in Computed Tomography Iterative Reconstruction.

Mahmoudi G, Ay M, Rahmim A, Ghadiri H J Med Signals Sens. 2020; 10(1):1-11.

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Ultra-low dose contrast CT pulmonary angiography in oncology patients using a high-pitch helical dual-source technology.

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Imaging of acute pulmonary embolism: an update.

Moore A, Wachsmann J, Chamarthy M, Panjikaran L, Tanabe Y, Rajiah P Cardiovasc Diagn Ther. 2018; 8(3):225-243.

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