Midkine: a Novel and Early Biomarker of Contrast-induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jan 29

PMID 25629054

Citations 8

Authors

Jolanta Malyszko

Hanna Bachorzewska-Gajewska

Ewa Koc-Zorawska

Jacek S Malyszko

Grazyna Kobus

Slawomir Dobrzycki

Affiliations

Soon will be listed here.

Abstract

We tested the hypothesis whether midkine could represent an early biomarker of contrast-induced acute kidney injury (CIAKI) in 89 patients with normal serum creatinine undergoing PCI. Midkine, serum and urinary NGAL, and cystatin C were evaluated before and 2, 4, 8, 24, and 48 hours after PCI using commercially available kits. Serum creatinine was assessed before and 24 and 48 hours after PCI. We found a significant rise in serum midkine as early as after 2 hours (P < 0.001) when compared to the baseline values. It was also significantly higher 4 hours after PCI and then returned to the baseline values after 24 hours and started to decrease after 48 hours. When contrast nephropathy was defined as an increase in serum creatinine by >25% of the baseline level 48 hours after PCI, the prevalence of CIN was 10%. Patients with CIN received significantly more contrast agent (P < 0.05), but durations of PCI were similar. Midkine was significantly higher 2, 4, and 8 hours after PCI in patients with CIN. Since the "window of opportunity" is narrow in CIAKI and time is limited to introduce proper treatment after initiating insult, particularly when patients are discharged within 24 hours after the procedure, midkine needs to be investigated as a potential early marker for renal ischemia and/or nephrotoxicity.

Citing Articles

Unveiling the Mysteries of Contrast-Induced Acute Kidney Injury: New Horizons in Pathogenesis and Prevention.

Wang Z, Wang Q, Gong X Toxics. 2024; 12(8).

PMID: 39195722 PMC: 11360536. DOI: 10.3390/toxics12080620.

Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective.

Gonzalez-Nicolas M, Gonzalez-Guerrero C, Goicoechea M, Bosca L, Valino-Rivas L, Lazaro A Int J Mol Sci. 2024; 25(6).

PMID: 38542410 PMC: 10970772. DOI: 10.3390/ijms25063438.

The Potential Biotherapeutic Targets of Contrast-Induced Acute Kidney Injury.

Cheng A, Li X Int J Mol Sci. 2023; 24(9).

PMID: 37175958 PMC: 10178966. DOI: 10.3390/ijms24098254.

NGAL as Biomarker of Clinical and Subclinical Damage of Kidney Function after Coronary Angiography.

Petrova I, Alexandrov A, Vladimirov G, Mateev H, Bogov I, Paskaleva I Diagnostics (Basel). 2023; 13(6).

PMID: 36980488 PMC: 10047760. DOI: 10.3390/diagnostics13061180.

Serum Midkine, estimated glomerular filtration rate and chronic kidney disease-related events in elderly women: Perth Longitudinal Study of Aging Women.

Wang J, Lewis J, Byrnes E, Wong G, Raymond W, Zhu K Sci Rep. 2020; 10(1):14499.

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