NGAL (neutrophil Gelatinase-associated Lipocalin) and Cystatin C: Are They Good Predictors of Contrast Nephropathy After Percutaneous Coronary Interventions in Patients with Stable Angina and Normal Serum Creatinine?

Overview

Journal Int J Cardiol

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2007 Jun 15

PMID 17566573

Citations 22

Authors

H Bachorzewska-Gajewska

J Malyszko

E Sitniewska

J S Malyszko

B Poniatowski

K Pawlak

S Dobrzycki

Affiliations

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Abstract

The aim of the study was to assess whether NGAL and cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n=60, mean age 60+/-11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI.

Citing Articles

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Chen Y, Fu Y, Wang S, Chen P, Pei Y, Zhang J Cardiovasc Diabetol. 2022; 21(1):252.

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Neutrophil Gelatinase-Associated Lipocalin as a Marker for Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Prospective Observational Analysis.

Sahu A, Goel P, Khanna R, Kumar S, Kapoor A, Tewari S Indian J Nephrol. 2022; 32(3):247-255.

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Pentoxifylline for the prevention of contrast-induced nephropathy in diabetic patients undergoing angioplasty: a randomized controlled trial.

Aslanabadi N, Afsar Gharebagh R, Moharramzadeh S, Entezari-Maleki T Int Urol Nephrol. 2019; 51(4):699-705.

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