Prediction of Creatinine Clearance from Serum Creatinine

Overview

Journal Nephron

Publisher Karger

Specialty Nephrology

Date 1976 Jan 1

PMID 1244564

Citations 3912

Authors

D W Cockcroft

M H GAULT

Affiliations

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Abstract

A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

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