Disease-specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2015 Jan 27

PMID 25619688

Citations 643

Authors

Jason M Norman

Scott A Handley

Megan T Baldridge

Lindsay Droit

Catherine Y Liu

Brian C Keller

Amal Kambal

Cynthia L Monaco

Guoyan Zhao

Phillip Fleshner

Thaddeus S Stappenbeck

Dermot P B McGovern

Ali Keshavarzian

Ece A Mutlu

Jenny Sauk

Dirk Gevers

Ramnik J Xavier

David Wang

Miles Parkes

Herbert W Virgin

Affiliations

Soon will be listed here.

Abstract

Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.

Citing Articles

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