Thaddeus S Stappenbeck
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Explore the profile of Thaddeus S Stappenbeck including associated specialties, affiliations and a list of published articles.
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156
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Recent Articles
1.
Zhou J, Lu Q, Hu Y, Fujii S, Espenschied S, Engelhart M, et al.
bioRxiv
. 2024 Nov;
PMID: 39554082
Modulation of immune tone at mucosal surfaces is critical to maintain homeostasis while facilitating the handling of emerging threats. One dynamic component of immune modulation is the phagocytosis and clearance...
2.
Kang L, Sarullo K, Marsh J, Lu L, Khonde P, Ma C, et al.
EBioMedicine
. 2024 Nov;
110:105440.
PMID: 39536395
Background: Alterations in ileal Paneth cell (PC) density have been described in gut inflammatory diseases such as Crohn's disease (CD) and could be used as a biomarker for disease prognosis....
3.
Sun S, Hodel M, Wang X, De Vicente J, Haritunians T, Debebe A, et al.
Sci Immunol
. 2024 Nov;
9(101):eadi7907.
PMID: 39514635
polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeutic strategy...
4.
Shrestha D, Pant B, Pant B, Roychowdhury S, Gandhirajan A, Cross E, et al.
J Leukoc Biol
. 2024 Sep;
117(2).
PMID: 39340428
Septic shock is associated with over 40% mortality. The immune response in septic shock is tightly regulated by cellular metabolism and transitions from early hyper-inflammation to later hypo-inflammation. Patients are...
5.
Lu Q, Hitch T, Zhou J, Dwidar M, Sangwan N, Lawrence D, et al.
Science
. 2024 Sep;
385(6716):eadk2536.
PMID: 39325906
Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional...
6.
Janova H, Zhao F, Desai P, Mack M, Thackray L, Stappenbeck T, et al.
J Clin Invest
. 2024 Aug;
134(21).
PMID: 39207863
Intestinal dysmotility syndromes have been epidemiologically associated with several antecedent bacterial and viral infections. To model this phenotype, we previously infected mice with the neurotropic flavivirus West Nile virus (WNV)...
7.
Hung C, Ma C, Panda S, Trsan T, Hodel M, Frein J, et al.
Mucosal Immunol
. 2024 Jul;
17(5):1019-1028.
PMID: 38992433
The prevalence of obesity in the United States has continued to increase over the past several decades. Understanding how diet-induced obesity modulates mucosal immunity is of clinical relevance. We previously...
8.
Ma C, Haritunians T, Gremida A, Syal G, Shah J, Yang S, et al.
J Crohns Colitis
. 2024 Jul;
PMID: 38953127
Background & Aims: Biomarkers that integrate genetic and environmental factors and predict outcome in complex immune diseases such as inflammatory bowel disease (IBD; including Crohn's disease [CD] and ulcerative colitis...
9.
Trsan T, Peng V, Krishna C, Ohara T, Beatty W, Sudan R, et al.
Dev Cell
. 2024 Jun;
59(18):2460-2476.e10.
PMID: 38942017
Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of inflammatory bowel disease. Certain risk genes...
10.
Braun T, Feng R, Amir A, Levhar N, Shacham H, Mao R, et al.
Nat Commun
. 2024 May;
15(1):3764.
PMID: 38704361
Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE,...