Mitochondrial Quality Control: Easy Come, Easy Go

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2015 Jan 18

PMID 25596427

Citations 38

Authors

Aleksandr Stotland

Roberta A Gottlieb

Affiliations

Soon will be listed here.

Abstract

"Friends come and go but enemies accumulate." - Arthur Bloch Mitochondrial networks in eukaryotic cells are maintained via regular cycles of degradation and biogenesis. These complex processes function in concert with one another to eliminate dysfunctional mitochondria in a specific and targeted manner and coordinate the biogenesis of new organelles. This review covers the two aspects of mitochondrial turnover, focusing on the main pathways and mechanisms involved. The review also summarizes the current methods and techniques for analyzing mitochondrial turnover in vivo and in vitro, from the whole animal proteome level to the level of single organelle.

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