PGC-1-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Jun 20

PMID 35721484

Authors

Lei Chen

Yuan Qin

Bilin Liu

Meng Gao

Anqi Li

Xue Li

Guohua Gong

Affiliations

Soon will be listed here.

Abstract

Mitochondria with structural and functional integrity are essential for maintaining mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many diseases. Peroxisome proliferator-activated receptor coactivator 1 (PGC-1), acted as a transcriptional cofactor, is abundant in the heart, which modulates mitochondrial biogenesis and mitochondrial dynamics and mitophagy to sustain a steady-state of mitochondria. Cumulative evidence suggests that dysregulation of PGC-1 is closely related to the onset and progression of heart failure. PGC-1 deficient-mice can lead to worse cardiac function under pressure overload compared to sham. Here, this review mainly focuses on what is known about its regulation in mitochondrial functions, as well as its crucial role in heart failure.

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