Ethical Considerations Regarding Classroom Use of Personal Genomic Information

Overview

Journal J Microbiol Biol Educ

Publisher American Society for Microbiology

Specialty Biology

Date 2015 Jan 10

PMID 25574277

Citations 4

Authors

Lisa S Parker

Robin Grubs

Affiliations

Soon will be listed here.

Abstract

Rapidly decreasing costs of genetic technologies-especially next-generation sequencing-and intensifying need for a clinical workforce trained in genomic medicine have increased interest in having students use personal genomic information to motivate and enhance genomics education. Numerous ethical issues attend classroom/pedagogical use of students' personal genomic information, including their informed decision to participate, pressures to participate, privacy concerns, and psychosocial sequelae of learning genomic information. This paper addresses these issues, advocates explicit discussion of these issues to cultivate students' ethical reasoning skills, suggests ways to mitigate potential harms, and recommends collection of ethically relevant data regarding pedagogical use of personal genomic information.

Citing Articles

Impacts of incorporating personal genome sequencing into graduate genomics education: a longitudinal study over three course years.

Linderman M, Sanderson S, Bashir A, Diaz G, Kasarskis A, Zinberg R BMC Med Genomics. 2018; 11(1):5.

PMID: 29382336 PMC: 5791365. DOI: 10.1186/s12920-018-0319-0.

Effects of Using Personal Genotype Data on Student Learning and Attitudes in a Pharmacogenomics Course.

Wiisanen Weitzel K, McDonough C, Elsey A, Burkley B, Cavallari L, Johnson J Am J Pharm Educ. 2016; 80(7):122.

PMID: 27756930 PMC: 5066925. DOI: 10.5688/ajpe807122.

Advancing Pharmacogenomics Education in the Core PharmD Curriculum through Student Personal Genomic Testing.

Adams S, Anderson K, Coons J, Smith R, Meyer S, Parker L Am J Pharm Educ. 2016; 80(1):3.

PMID: 26941429 PMC: 4776296. DOI: 10.5688/ajpe8013.

Anticipation of Personal Genomics Data Enhances Interest and Learning Environment in Genomics and Molecular Biology Undergraduate Courses.

Weber K, Jensen J, Johnson S PLoS One. 2015; 10(8):e0133486.

PMID: 26241308 PMC: 4524698. DOI: 10.1371/journal.pone.0133486.

References

Haspel R, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P . A call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010; 133(6):832-4. DOI: 10.1309/AJCPN6Q1QKCLYKXM. View

Forrow L, Arnold R, Parker L . Preventive ethics: expanding the horizons of clinical ethics. J Clin Ethics. 1993; 4(4):287-94. View

Ormond K, Hudgins L, Ladd J, Magnus D, Greely H, Cho M . Medical and graduate students' attitudes toward personal genomics. Genet Med. 2011; 13(5):400-8. DOI: 10.1097/GIM.0b013e31820562f6. View

Callier S . Swabbing students: should universities be allowed to facilitate educational DNA testing?. Am J Bioeth. 2012; 12(4):32-40. PMC: 3390747. DOI: 10.1080/15265161.2012.656803. View

Check Hayden E . Technology: The $1,000 genome. Nature. 2014; 507(7492):294-5. DOI: 10.1038/507294a. View

Hamilton R, Williams J, Bowers B, Calzone K . Life trajectories, genetic testing, and risk reduction decisions in 18-39 year old women at risk for hereditary breast and ovarian cancer. J Genet Couns. 2008; 18(2):147-59. PMC: 2834272. DOI: 10.1007/s10897-008-9200-1. View

Werner-Lin A . Beating the biological clock: the compressed family life cycle of young women with BRCA gene alterations. Soc Work Health Care. 2008; 47(4):416-37. DOI: 10.1080/00981380802173509. View

Salari K, Karczewski K, Hudgins L, Ormond K . Evidence that personal genome testing enhances student learning in a course on genomics and personalized medicine. PLoS One. 2013; 8(7):e68853. PMC: 3720862. DOI: 10.1371/journal.pone.0068853. View

Kuehn B . Inconsistent results, inaccurate claims plague direct-to-consumer gene tests. JAMA. 2010; 304(12):1313-5. DOI: 10.1001/jama.2010.1328. View

10.

Weijer C, Emanuel E . Ethics. Protecting communities in biomedical research. Science. 2000; 289(5482):1142-4. DOI: 10.1126/science.289.5482.1142. View

11.

Rogers J, Taylor A . Teaching about genetic testing issues in the undergraduate classroom: a case study. J Genet Couns. 2011; 20(3):231-40. DOI: 10.1007/s10897-011-9352-2. View

12.

Walt D, Kuhlik A, Epstein S, Demmer L, Knight M, Chelmow D . Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med. 2010; 13(1):63-6. DOI: 10.1097/GIM.0b013e3181f872ac. View

13.

Sanderson S, Linderman M, Kasarskis A, Bashir A, Diaz G, Mahajan M . Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort study. Genome Med. 2013; 5(12):113. PMC: 3971344. DOI: 10.1186/gm518. View

14.

Karczewski K, Tirrell R, Cordero P, Tatonetti N, Dudley J, Salari K . Interpretome: a freely available, modular, and secure personal genome interpretation engine. Pac Symp Biocomput. 2011; :339-350. PMC: 4809242. View

15.

Boguski M, Boguski R, Berman M . Personal genotypes are teachable moments. Genome Med. 2013; 5(3):22. PMC: 3706876. DOI: 10.1186/gm426. View

16.

Hamilton R, Hurley K . Conditions and consequences of a BRCA mutation in young, single women of childbearing age. Oncol Nurs Forum. 2010; 37(5):627-34. DOI: 10.1188/10.ONF.627-634. View

17.

Soto-Cruz I, Legorreta-Herrera M . Analysis of a p53 mutation associated with cancer susceptibility for biochemistry and genetic laboratory courses. Biochem Mol Biol Educ. 2011; 37(4):236-42. DOI: 10.1002/bmb.20304. View

18.

Wolf S, Lawrenz F, Nelson C, Kahn J, Cho M, Clayton E . Managing incidental findings in human subjects research: analysis and recommendations. J Law Med Ethics. 2008; 36(2):219-48, 211. PMC: 2575242. DOI: 10.1111/j.1748-720X.2008.00266.x. View

19.

Hamilton R . Being young, female, and BRCA positive. Am J Nurs. 2012; 112(10):26-31, quiz 46, 32. DOI: 10.1097/01.NAJ.0000421021.62295.3b. View

20.

Daley L, Wagner J, Himmel T, McPartland K, Katsanis S, Shriver M . Personal DNA testing in college classrooms: perspectives of students and professors. Genet Test Mol Biomarkers. 2013; 17(6):446-52. DOI: 10.1089/gtmb.2012.0404. View