Kruppel-like Factors in Muscle Health and Disease

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2014 Dec 23

PMID 25528994

Citations 25

Authors

Domenick A Prosdocimo

M Khaled Sabeh

Mukesh K Jain

Affiliations

Soon will be listed here.

Abstract

Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.

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