Genetic Factors in Treatment-related Cardiovascular Complications in Survivors of Childhood Acute Lymphoblastic Leukemia

Overview

Journal Pharmacogenomics

Specialties Genetics
Pharmacology

Date 2021 Sep 10

PMID 34505544

Citations 1

Authors

Kateryna Petrykey

Aziz M Rezgui

Mathilde Le Guern

Patrick Beaulieu

Pascal St-Onge

Simon Drouin

Laurence Bertout

Fan Wang

Jessica L Baedke

Yutaka Yasui

Melissa M Hudson

Marie-Josee Raboisson

Caroline Laverdiere

Daniel Sinnett

Gregor U Andelfinger

Maja Krajinovic

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease represents one of the main causes of secondary morbidity and mortality in patients with childhood cancer. To further address this issue, we analyzed cardiovascular complications in relation to common and rare genetic variants derived through whole-exome sequencing from childhood acute lymphoblastic leukemia survivors (PETALE cohort). Significant associations were detected among common variants in the gene, left ventricular ejection fraction (p ≤ 0.0005), and fractional shortening (p ≤ 0.001). Rare variants enrichment in the , and was observed in relation to left ventricular ejection fraction, and in and genes in relation to fractional shortening. Following stratification according to risk groups, the modulatory effect of rare variants was additionally found in the , and genes. None of the associations was replicated in St-Jude Lifetime Cohort Study. Further studies are needed to confirm whether the described genetic markers may be useful in identifying patients at increased risk of these complications.

Citing Articles

Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study.

Petrykey K, Lippe S, Sultan S, Robaey P, Drouin S, Affret-Bertout L Cancer Epidemiol Biomarkers Prev. 2023; 33(2):234-243.

PMID: 38051303 PMC: 10903523. DOI: 10.1158/1055-9965.EPI-23-0634.

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