Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia

Overview

Journal Am J Hypertens

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2014 Dec 20

PMID 25523295

Citations 11

Authors

Cassandra N Spracklen

Audrey F Saftlas

Elizabeth W Triche

Andrew Bjonnes

Brendan Keating

Richa Saxena

Patrick J Breheny

Andrew T DeWan

Jennifer G Robinson

Josephine Hoh

Kelli K Ryckman

Affiliations

Soon will be listed here.

Abstract

Background: Large epidemiologic studies support the role of dyslipidemia in preeclampsia; however, the etiology of preeclampsia or whether dyslipidemia plays a causal role remains unclear. We examined the association between the genetic predisposition to dyslipidemia and risk of preeclampsia using validated genetic markers of dyslipidemia.

Methods: Preeclampsia cases (n = 164) and normotensive controls (n = 110) were selected from live birth certificates to nulliparous Iowa women during the period August 2002 to May 2005. Disease status was verified by medical chart review. Genetic predisposition to dyslipidemia was estimated by 4 genetic risk scores (GRS) (total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides) on the basis of established loci for blood lipids. Logistic regression analyses were used to evaluate the relationships between each of the 4 genotype scores and preeclampsia. Replication analyses were performed in an independent, US population of preeclampsia cases (n = 516) and controls (n = 1,097) of European ancestry.

Results: The GRS related to higher levels of TC, LDL-C, and triglycerides demonstrated no association with the risk of preeclampsia in either the Iowa or replication population. The GRS related to lower HDL-C was marginally associated with an increased risk for preeclampsia (odds ratio (OR) = 1.03, 95% confidence interval (CI) = 0.99-1.07; P = 0.10). In the independent replication population, the association with the HDL-C GRS was also marginally significant (OR = 1.03, 95% CI: 1.00-1.06; P = 0.04).

Conclusions: Our data suggest a potential effect between the genetic predisposition to dyslipidemic levels of HDL-C and an increased risk of preeclampsia, and, as such, suggest that dyslipidemia may be a component along the causal pathway to preeclampsia.

Citing Articles

Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy.

Nurkkala J, Kauko A, FinnGen , Laivuori H, Saarela T, Tyrmi J J Hypertens. 2023; 41(3):380-387.

PMID: 36947680 PMC: 9894151. DOI: 10.1097/HJH.0000000000003336.

Genome-wide polygenic risk scores for hypertensive disease during pregnancy can also predict the risk for long-term cardiovascular disease.

Lee S, Shivakumar M, Xiao B, Jung S, Nam Y, Yun J Am J Obstet Gynecol. 2023; 229(3):298.e1-298.e19.

PMID: 36933686 PMC: 10504416. DOI: 10.1016/j.ajog.2023.03.013.

Association of clinical and genetic risk factors with management of dyslipidaemia: analysis of repeated cross-sectional studies in the general population of Lausanne, Switzerland.

Chekanova V, Abolhassani N, Vaucher J, Marques-Vidal P BMJ Open. 2023; 13(2):e065409.

PMID: 36810165 PMC: 9945309. DOI: 10.1136/bmjopen-2022-065409.

Prediction of Differentially Expressed Genes and a Diagnostic Signature of Preeclampsia via Integrated Bioinformatics Analysis.

Huang S, Cai S, Li H, Zhang W, Xiao H, Yu D Dis Markers. 2022; 2022:5782637.

PMID: 35711567 PMC: 9197614. DOI: 10.1155/2022/5782637.

Pre-pregnancy blood pressure and pregnancy outcomes: a nationwide population-based study.

Jung Y, Oh G, Noh E, Lee H, Oh M, Park J BMC Pregnancy Childbirth. 2022; 22(1):226.

PMID: 35305601 PMC: 8934452. DOI: 10.1186/s12884-022-04573-7.

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