Brendan Keating
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Explore the profile of Brendan Keating including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Zanoni F, Obayemi J, Gandla D, Castellano G, Keating B, Keating B
Kidney Int
. 2024 Dec;
107(3):424-433.
PMID: 39710162
The advent of more affordable genomic analytical pipelines has facilitated the expansion of genetic studies in kidney transplantation. Advances in genetic sequencing have allowed for a greater understanding of the...
2.
Mankowski M, Gragert L, Keating B, Lonze B, Segev D, Montgomery R, et al.
Am J Transplant
. 2024 Dec;
PMID: 39631566
Human leukocyte antigen-level matching in US kidney allocation has been deemphasized due to its role in elevating racial disparities. Molecular matching based on eplets might improve risk stratification compared to...
3.
Mattoo A, Jaffe I, Keating B, Montgomery R, Mangiola M
Front Genet
. 2024 Oct;
15:1442018.
PMID: 39415982
Optimizing immunologic compatibility in organ transplantation extends beyond the conventional approach of Human Leukocyte Antigen (HLA) antigen matching, which exhibits significant limitations. A broader comprehension of the roles of classical...
4.
Obayemi J, Callans L, Nair N, Gao H, Gandla D, Loza B, et al.
J Clin Pharmacol
. 2024 May;
64(8):944-952.
PMID: 38766706
Tacrolimus metabolism is heavily influenced by the CYP3A5 genotype, which varies widely among African Americans (AA). We aimed to assess the performance of a published genotype-informed tacrolimus dosing model in...
5.
Zanoni F, Neugut Y, Obayemi J, Liu L, Zhang J, Ratner L, et al.
Am J Transplant
. 2024 Feb;
24(6):1003-1015.
PMID: 38331047
African American (AA) kidney recipients have a higher risk of allograft rejection and failure compared to non-AAs, but to what extent these outcomes are due to genetic versus environmental effects...
6.
Loupy A, Goutaudier V, Giarraputo A, Mezine F, Morgand E, Robin B, et al.
Lancet
. 2023 Aug;
402(10408):1158-1169.
PMID: 37598688
Background: Cross-species immunological incompatibilities have hampered pig-to-human xenotransplantation, but porcine genome engineering recently enabled the first successful experiments. However, little is known about the immune response after the transplantation of...
7.
Moazami N, Stern J, Khalil K, Kim J, Narula N, Mangiola M, et al.
Nat Med
. 2023 Jul;
29(8):1989-1997.
PMID: 37488288
Genetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart...
8.
Romero E, Tabak E, Fishbein G, Litovsky S, Tallaj J, Liem D, et al.
Clin Transplant
. 2023 May;
37(9):e15011.
PMID: 37151104
Background: Endomyocardial biopsy (EMB) is currently considered the gold standard for diagnosing cardiac allograft rejection. However, significant limitations related to histological interpretation variability are well-recognized. We sought to develop a...
9.
Alkhamis F, Alabdali M, AlSulaiman A, Alamri A, Alali R, Akhtar M, et al.
Funct Integr Genomics
. 2023 Mar;
23(2):102.
PMID: 36973604
Ischemic stroke represents a significant societal burden across the globe. Rare high penetrant monogenic variants and less pathogenic common single nucleotide polymorphisms (SNPs) have been described as being associated with...
10.
Xiao B, Velez Edwards D, Lucas A, Drivas T, Gray K, Keating B, et al.
J Am Heart Assoc
. 2023 Feb;
12(5):e026561.
PMID: 36846987
Background Cardiometabolic diseases are highly comorbid, but their relationship with female-specific or overwhelmingly female-predominant health conditions (breast cancer, endometriosis, pregnancy complications) is understudied. This study aimed to estimate the cross-trait...