» Articles » PMID: 25506234

Mechanism Linking Diabetes Mellitus and Obesity

Overview
Publisher Dove Medical Press
Specialty Endocrinology
Date 2014 Dec 16
PMID 25506234
Citations 379
Authors
Affiliations
Soon will be listed here.
Abstract

Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts.

Citing Articles

Meta-analysis of risk factors for recurrent gestational diabetes mellitus.

Lu Y, Huang J, Yan J, Wei Q, He M, Yuan C BMC Pregnancy Childbirth. 2025; 25(1):257.

PMID: 40057727 PMC: 11889910. DOI: 10.1186/s12884-025-07367-9.


Fermented sugarcane juice-derived probiotic RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation.

Kumari V, Ramu R, Huligere S, Patil S, Nayakvadi S, Bijoor S Front Microbiol. 2025; 15:1502751.

PMID: 39943964 PMC: 11814229. DOI: 10.3389/fmicb.2024.1502751.


Biochemical markers to detect protein malnutrition in type 2 diabetes and liver cirrhosis patients.

Mohammedsaeed W, Binjawhar D, Surrati A Medicine (Baltimore). 2025; 104(5):e41376.

PMID: 39889178 PMC: 11789901. DOI: 10.1097/MD.0000000000041376.


Deleterious Effects of Yoyo Dieting and Resistant Starch on Gastrointestinal Morphology.

Phuong-Nguyen K, Mahmood M, Rivera L Nutrients. 2024; 16(23).

PMID: 39683609 PMC: 11644255. DOI: 10.3390/nu16234216.


Sweetening the deal: an infodemiological study of worldwide interest in semaglutide using Google Trends extended for health application programming interface.

Raubenheimer J, Myburgh P, Bhagavathula A BMC Glob Public Health. 2024; 2(1):63.

PMID: 39681910 PMC: 11622965. DOI: 10.1186/s44263-024-00095-w.


References
1.
Cnop M, Landchild M, Vidal J, Havel P, Knowles N, Carr D . The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes. 2002; 51(4):1005-15. DOI: 10.2337/diabetes.51.4.1005. View

2.
Kahn S . Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001; 86(9):4047-58. DOI: 10.1210/jcem.86.9.7713. View

3.
Mathieu C, Badenhoop K . Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab. 2005; 16(6):261-6. DOI: 10.1016/j.tem.2005.06.004. View

4.
McKeigue P, Shah B, Marmot M . Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991; 337(8738):382-6. DOI: 10.1016/0140-6736(91)91164-p. View

5.
Marcial J, Altieri P, Banchs H, Escobales N, Crespo M . Metabolic syndrome among Puerto Ricans and other Hispanic populations. P R Health Sci J. 2011; 30(3):145-51. View