Cytokine-induced Dicing and Splicing in the Beta-cell and the Immune Response in Type 1 Diabetes

Overview

Journal Diabetes

Specialty Endocrinology

Date 2010 Jan 28

PMID 20103713

Citations 6

Authors

John C Hutton

Howard W Davidson

Affiliations

Soon will be listed here.

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References

Martin C, Bischof L, Bergman B, HORNBUCKLE L, Hilliker C, Frigeri C . Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J Biol Chem. 2001; 276(27):25197-207. DOI: 10.1074/jbc.M101549200. View

Eissa N, Strauss A, Haggerty C, Choo E, Chu S, Moss J . Alternative splicing of human inducible nitric-oxide synthase mRNA. tissue-specific regulation and induction by cytokines. J Biol Chem. 1996; 271(43):27184-7. DOI: 10.1074/jbc.271.43.27184. View

Haider S, Knofler M . Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta. 2008; 30(2):111-23. PMC: 2974215. DOI: 10.1016/j.placenta.2008.10.012. View

Peakman M, Stevens E, Lohmann T, Narendran P, Dromey J, Alexander A . Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest. 1999; 104(10):1449-57. PMC: 409844. DOI: 10.1172/JCI7936. View

Nambiar M, Enyedy E, Warke V, Krishnan S, Dennis G, Kammer G . Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus. J Autoimmun. 2001; 16(2):133-42. DOI: 10.1006/jaut.2000.0475. View

Kiesel U, Kolb H . Suppressive effect of antibodies to immune response gene products on the development of low-dose streptozotocin-induced diabetes. Diabetes. 1983; 32(9):869-71. DOI: 10.2337/diab.32.9.869. View

Park Y, Kawasaki E, Kelemen K, Yu L, Schiller M, Rewers M . Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes. Diabetologia. 2000; 43(10):1293-301. DOI: 10.1007/s001250051525. View

Sarkar S, Kutlu B, Velmurugan K, Kizaka-Kondoh S, Lee C, Wong R . Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia. 2009; 52(6):1092-101. DOI: 10.1007/s00125-009-1331-x. View

Ortis F, Naamane N, Flamez D, Ladriere L, Moore F, Cunha D . Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes. 2009; 59(2):358-74. PMC: 2809955. DOI: 10.2337/db09-1159. View

10.

Nielsen C, Ohm-Laursen L, Barington T, Husby S, Lillevang S . Alternative splice variants of the human PD-1 gene. Cell Immunol. 2005; 235(2):109-16. DOI: 10.1016/j.cellimm.2005.07.007. View

11.

Yewdell J, Nicchitta C . The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol. 2006; 27(8):368-73. DOI: 10.1016/j.it.2006.06.008. View

12.

Arden S, Zahn T, Steegers S, Webb S, Bergman B, OBrien R . Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999; 48(3):531-42. DOI: 10.2337/diabetes.48.3.531. View

13.

Drappa J, Vaishnaw A, Sullivan K, Chu J, Elkon K . Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med. 1996; 335(22):1643-9. DOI: 10.1056/NEJM199611283352204. View

14.

Yip L, Su L, Sheng D, Chang P, Atkinson M, Czesak M . Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol. 2009; 10(9):1026-33. PMC: 2752139. DOI: 10.1038/ni.1773. View

15.

Kutlu B, Cardozo A, Darville M, Kruhoffer M, Magnusson N, Orntoft T . Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes. 2003; 52(11):2701-19. DOI: 10.2337/diabetes.52.11.2701. View

16.

Yoshizumi M, Nakamura T, Kato M, Ishioka T, Kozawa K, Wakamatsu K . Release of cytokines/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT. Cell Biol Int. 2008; 32(11):1405-11. DOI: 10.1016/j.cellbi.2008.08.011. View

17.

Jacobsen M, Hoffmann S, Cepok S, Stei S, Ziegler A, Sommer N . A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule. Immunogenetics. 2002; 54(3):158-63. DOI: 10.1007/s00251-002-0455-7. View

18.

Dogra R, Vaidyanathan P, Prabakar K, Marshall K, Hutton J, Pugliese A . Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Diabetologia. 2006; 49(5):953-7. DOI: 10.1007/s00125-006-0185-8. View

19.

Ehses J, Ellingsgaard H, Boni-Schnetzler M, Donath M . Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction. Arch Physiol Biochem. 2009; 115(4):240-7. DOI: 10.1080/13813450903025879. View

20.

Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C . Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes. 2001; 50(4):895-900. DOI: 10.2337/diabetes.50.4.895. View