Recent Advancements in Drug Delivery System of Flavonoids with a Special Emphasis on the Flavanone Naringenin: Exploring Their Application in Wound Healing and Associated Processes

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2024 Nov 22

PMID 39576423

Authors

Ankit Chowdhury

Bapi Gorain

Papiya Mitra Mazumder

Affiliations

Soon will be listed here.

Abstract

Numerous flavonoids have been identified in citrus fruits which show potential to cure several complex diseases. These natural polyphenolic bioactive compounds are the secondary metabolites of various plants, among which naringenin has been explored in several pre-clinical research for its beneficial role in promoting health by modulating various biochemical processes. Its antioxidant, anti-inflammatory, and anti-microbial effects have been projected toward healing of wounds. Further, its application has also been shown to regrow vascular networks, which are known to facilitate the healing of chronic wounds. Thus, the potential of naringenin to modulate various molecular pathways aids in the healing process of wounds. Considering the recent literature, an update has been attempted to present the correlation between the healing mechanisms of wounds by the application of naringenin. Furthermore, the application of naringenin is challenging because of its properties of poor solubility and limited permeability, which can be overcome by the nanotechnology platform. Thus, several nanocarriers that have been employed for the improvement of naringenin delivery are highlighted. Thereby, it can be concluded that a suitable nanocarrier of naringenin could be an effective tool in treating wounds to improve the quality of life of such patients.

Citing Articles

Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability.

Hu L, Luo Y, Yang J, Cheng C Molecules. 2025; 30(5).

PMID: 40076406 PMC: 11902153. DOI: 10.3390/molecules30051184.

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