Kinins Act on B1 or B2 Receptors to Release Conjointly Endothelium-derived Relaxing Factor and Prostacyclin from Bovine Aortic Endothelial Cells

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1989 Apr 1

PMID 2545298

Citations 18

Authors

P DOrleans-Juste

G De Nucci

J R Vane

Affiliations

Soon will be listed here.

Abstract

1. Bradykinin (Bk) induced the coupled release of endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) from bovine aortic endothelial cells grown in culture. The B2 kinin receptor antagonist, [D-Arg0,Hyp3,Thi5,8,D-Phe7]-Bk, abolished this release by Bk. 2. Des-Arg9-Bk, a B1 kinin receptor agonist, also induced the release of EDRF and PGI2, but much higher concentrations were required to obtain a similar release to that induced by Bk. 3. [Leu8],des-Arg9-Bk, a B1 receptor antagonist, significantly reduced the response to des-Arg9-Bk without affecting the release induced by Bk. 4. The release of EDRF and PGI2 induced by arachidonic acid or ADP was not significantly affected by the B2 or the B1 antagonist. 5. We conclude, therefore, that Bk and des-Arg9-Bk were acting respectively on B2 and B1 bradykinin receptors. 6. The possible role of kinin receptors in the release of EDRF and PGI2 from endothelial cells is discussed.

Citing Articles

In Vivo Effects of Bradykinin B2 Receptor Agonists with Varying Susceptibility to Peptidases.

Jean M, Gera L, Charest-Morin X, Marceau F, Bachelard H Front Pharmacol. 2016; 6:306.

PMID: 26793104 PMC: 4709452. DOI: 10.3389/fphar.2015.00306.

Analysis of erectile responses to bradykinin in the anesthetized rat.

Edward J, Pankey E, Jupiter R, Lasker G, Yoo D, Reddy V Am J Physiol Heart Circ Physiol. 2015; 309(3):H499-511.

PMID: 26055796 PMC: 4525086. DOI: 10.1152/ajpheart.00765.2014.

PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis.

Kolte D, Bryant J, Gibson G, Wang J, Shariat-Madar Z Cardiovasc Hematol Agents Med Chem. 2012; 10(2):154-66.

PMID: 22352684 PMC: 4905573. DOI: 10.2174/187152512800388939.

Cross-talk between the complement and the kinin system in vascular permeability.

Bossi F, Peerschke E, Ghebrehiwet B, Tedesco F Immunol Lett. 2011; 140(1-2):7-13.

PMID: 21762728 PMC: 3162365. DOI: 10.1016/j.imlet.2011.06.006.

The kallikrein-kinin system in health and in diseases of the kidney.

Kakoki M, Smithies O Kidney Int. 2009; 75(10):1019-30.

PMID: 19190676 PMC: 3733452. DOI: 10.1038/ki.2008.647.

References

Mastrangelo D, Mathison R, Huggel H, Dion S, DOrleans-Juste P, Rhaleb N . The rat isolated portal vein: a preparation sensitive to neurokinins, particularly neurokinin B. Eur J Pharmacol. 1987; 134(3):321-6. DOI: 10.1016/0014-2999(87)90363-3. View

Churchill L, Ward P . Relaxation of isolated mesenteric arteries by des-Arg9-bradykinin stimulation of B1 receptors. Eur J Pharmacol. 1986; 130(1-2):11-8. DOI: 10.1016/0014-2999(86)90178-0. View

DeBlois D, MARCEAU F . The ability of des-Arg9-bradykinin to relax rabbit isolated mesenteric arteries is acquired during in vitro incubation. Eur J Pharmacol. 1987; 142(1):141-4. DOI: 10.1016/0014-2999(87)90664-9. View

Waeber B, Aubert J, Nussberger J, Vavrek R, Stewart J, Brunner H . Influence of bradykinin on blood pressure regulation of spontaneously hypertensive rats maintained on different sodium intakes. Clin Exp Pharmacol Physiol. 1987; 14(8):659-64. DOI: 10.1111/j.1440-1681.1987.tb01887.x. View

Aubert J, Waeber B, Nussberger J, Vavrek R, Stewart J, Brunner H . Influence of endogenous bradykinin on acute blood pressure response to vasopressors in normotensive rats assessed with a bradykinin antagonist. J Cardiovasc Pharmacol. 1988; 11(1):51-5. DOI: 10.1097/00005344-198801000-00008. View

Carbonell L, Carretero O, Stewart J, Scicli A . Effect of a kinin antagonist on the acute antihypertensive activity of enalaprilat in severe hypertension. Hypertension. 1988; 11(3):239-43. DOI: 10.1161/01.hyp.11.3.239. View

Nucci G, Gryglewski R, Warner T, Vane J . Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled. Proc Natl Acad Sci U S A. 1988; 85(7):2334-8. PMC: 279986. DOI: 10.1073/pnas.85.7.2334. View

Cahill M, Fishman J, Polgar P . Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. Agents Actions. 1988; 24(3-4):224-31. DOI: 10.1007/BF02028275. View

Nucci G, Warner T, Vane J . Effect of captopril on the bradykinin-induced release of prostacyclin from guinea-pig lungs and bovine aortic endothelial cells. Br J Pharmacol. 1988; 95(3):783-8. PMC: 1854206. DOI: 10.1111/j.1476-5381.1988.tb11705.x. View

10.

Vane J . THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD. Br J Pharmacol Chemother. 1964; 23:360-73. PMC: 1704098. DOI: 10.1111/j.1476-5381.1964.tb01592.x. View

11.

Berry H, Collier J, Vane J . The generation of kinins in the blood of dogs during hypotension due to haemorrhage. Clin Sci. 1970; 39(3):349-65. DOI: 10.1042/cs0390349. View

12.

Case D, Wallace J, Keim H, Weber M, Drayer J, White R . Estimating renin participation in hypertension: superiority of converting enzyme inhibitor over saralasin. Am J Med. 1976; 61(5):790-6. DOI: 10.1016/0002-9343(76)90160-1. View

13.

Regoli D, Barabe J, Park W . Receptors for bradykinin in rabbit aortae. Can J Physiol Pharmacol. 1977; 55(4):855-67. DOI: 10.1139/y77-115. View

14.

Gavras H, Brunner H, Turini G, KERSHAW G, Tifft C, Cuttelod S . Antihypertensive effect of the oral angiotensin converting-enzyme inhibitor SQ 14225 in man. N Engl J Med. 1978; 298(18):991-5. DOI: 10.1056/NEJM197805042981803. View

15.

Salmon J . A radioimmunoassay for 6-keto-prostaglandin F1alpha. Prostaglandins. 1978; 15(3):383-97. DOI: 10.1016/0090-6980(78)90122-3. View

16.

Carretero O, Miyazaki S, Scicli A . Role of kinins in the acute antihypertensive effect of the converting enzyme inhibitor, captopril. Hypertension. 1981; 3(1):18-22. DOI: 10.1161/01.hyp.3.1.18. View

17.

Regoli D, Barabe J . Pharmacology of bradykinin and related kinins. Pharmacol Rev. 1980; 32(1):1-46. View

18.

Altura B, Chand N . Bradykinin-induced relaxation of renal and pulmonary arteries is dependent upon intact endothelial cells. Br J Pharmacol. 1981; 74(1):10-11. PMC: 2071891. DOI: 10.1111/j.1476-5381.1981.tb09948.x. View

19.

Cherry P, FURCHGOTT R, Zawadzki J, Jothianandan D . Role of endothelial cells in relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci U S A. 1982; 79(6):2106-10. PMC: 346132. DOI: 10.1073/pnas.79.6.2106. View

20.

Scicli A, Mindroiu T, Scicli G, Carretero O . Blood kinins, their concentration in normal subjects and in patients with congenital deficiency in plasma prekallikrein and kininogen. J Lab Clin Med. 1982; 100(1):81-93. View