The VP7 Gene of a New G Serotype of Human Rotavirus (B37) is Similar to G3 Proteins in the Antigenic C Region

Overview

Journal Virology

Specialty Microbiology

Date 1989 May 1

PMID 2541556

Citations 20

Authors

C P Hum

M L Dyall-Smith

I H HOLMES

Affiliations

Soon will be listed here.

Abstract

The human rotavirus isolate B37 has a characteristic "super-short" RNA electropherotype and has been shown to represent a new VP7 serotype (M. J. Albert, L. E. Unicomb, and R. F. Bishop, 1987, J. Clin. Microbiol. 25, 183-185). The VP7 gene was cloned, and its nucleotide and predicted amino acid sequences were compared to other published VP7 gene sequences. Consistent with the serological evidence, two major antigenic regions of the B37 VP7 (i.e., regions A and B) differ in sequence from those of other G serotypes. Unexpectedly, the C antigenic region shows close similarity to G3 rotaviruses, but we were unable to detect a serological relationship using serotype 3 monoclonal antibodies.

Citing Articles

Genomic diversity of group A rotaviruses from wild boars and domestic pigs in Japan: wide prevalence of NSP5 carrying the H2 genotype.

Shizawa S, Fukuda F, Kikkawa Y, Oi T, Takemae H, Masuda T Arch Virol. 2024; 169(3):63.

PMID: 38451342 DOI: 10.1007/s00705-023-05954-9.

Molecular characteristics of German G8P[4] rotavirus strain GER1H-09 suggest that a genotyping and subclassification update is required for G8.

Pietsch C, Petersen L, Patzer L, Liebert U J Clin Microbiol. 2009; 47(11):3569-76.

PMID: 19741083 PMC: 2772587. DOI: 10.1128/JCM.01471-09.

Diversity in Indian equine rotaviruses: identification of genotype G10,P6[1] and G1 strains and a new VP7 genotype (G16) strain in specimens from diarrheic foals in India.

Gulati B, Deepa R, Singh B, Rao C J Clin Microbiol. 2006; 45(3):972-8.

PMID: 17135436 PMC: 1829150. DOI: 10.1128/JCM.01696-06.

Detection and characterization of novel rotavirus strains in the United States.

Ramachandran M, Gentsch J, Parashar U, Jin S, WOODS P, Holmes J J Clin Microbiol. 1998; 36(11):3223-9.

PMID: 9774569 PMC: 105305. DOI: 10.1128/JCM.36.11.3223-3229.1998.

Molecular epidemiology of human rotaviruses in Manipur: genome analysis of rotaviruses of long electropherotype and subgroup I.

Krishnan T, Burke B, Shen S, Naik T, Desselberger U Arch Virol. 1994; 134(3-4):279-92.

PMID: 8129617 DOI: 10.1007/BF01310567.