Epigenetic Nutraceutical Diets in Alzheimer's Disease

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2014 Nov 13

PMID 25389957

Citations 20

Authors

S Davinelli

V Calabrese

D Zella

G Scapagnini

Affiliations

Soon will be listed here.

Abstract

There is growing support that environmental influences and individual genetic susceptibility may increase the incidence and accelerate the onset of Alzheimer's disease (AD). Epigenetic mechanisms encompass a complex regulatory network of modifications with considerable impact on health and disease risk. Abnormal epigenetic regulation is a hallmark in many pathological conditions including AD. It is well recognized that numerous bioactive dietary components mediate epigenetic modifications associated with the pathophysiology of several diseases. Although the influences of dietary factors on epigenetic regulation have been extensively investigated, only few studies have explored the effects of specific food components in regulating epigenetic patterns during neurodegeneration and AD. Epigenetic nutritional research has substantial potential for AD and may represent a window of opportunity to complement other interventions. Here, we provide a brief overview of the main mechanisms involved in AD, some of which may be epigenetically modulated by bioactive food.

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References

Milenkovic D, Jude B, Morand C . miRNA as molecular target of polyphenols underlying their biological effects. Free Radic Biol Med. 2013; 64:40-51. DOI: 10.1016/j.freeradbiomed.2013.05.046. View

Ross S, Davis C . MicroRNA, nutrition, and cancer prevention. Adv Nutr. 2012; 2(6):472-85. PMC: 3226385. DOI: 10.3945/an.111.001206. View

Howitz K, Bitterman K, Cohen H, Lamming D, Lavu S, Wood J . Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003; 425(6954):191-6. DOI: 10.1038/nature01960. View

Liu Z, Xie Z, Jones W, Pavlovicz R, Liu S, Yu J . Curcumin is a potent DNA hypomethylation agent. Bioorg Med Chem Lett. 2008; 19(3):706-9. DOI: 10.1016/j.bmcl.2008.12.041. View

Nerurkar P, Johns L, Buesa L, Kipyakwai G, Volper E, Sato R . Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation. 2011; 8:64. PMC: 3129574. DOI: 10.1186/1742-2094-8-64. View

Govindarajan N, Agis-Balboa R, Walter J, Sananbenesi F, Fischer A . Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J Alzheimers Dis. 2011; 26(1):187-97. DOI: 10.3233/JAD-2011-110080. View

Shankar S, Kumar D, Srivastava R . Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition. Pharmacol Ther. 2012; 138(1):1-17. PMC: 4153856. DOI: 10.1016/j.pharmthera.2012.11.002. View

West R, Lee J, Maroun L . Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. J Mol Neurosci. 1995; 6(2):141-6. DOI: 10.1007/BF02736773. View

Nunez-Iglesias J, Liu C, Morgan T, Finch C, Zhou X . Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One. 2010; 5(2):e8898. PMC: 2813862. DOI: 10.1371/journal.pone.0008898. View

10.

Feil R, Fraga M . Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 2012; 13(2):97-109. DOI: 10.1038/nrg3142. View

11.

Fang M, Wang J, Zhang X, Geng Y, Hu Z, Rudd J . The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease. Toxicol Lett. 2011; 209(1):94-105. DOI: 10.1016/j.toxlet.2011.11.032. View

12.

Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y . MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2010; 33(3):522-34. DOI: 10.1016/j.neurobiolaging.2010.04.034. View

13.

Fuso A, Seminara L, Cavallaro R, Danselmi F, Scarpa S . S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci. 2004; 28(1):195-204. DOI: 10.1016/j.mcn.2004.09.007. View

14.

Fang M, Wang Y, Ai N, Hou Z, Sun Y, Lu H . Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 2003; 63(22):7563-70. View

15.

Vepsalainen S, Koivisto H, Pekkarinen E, Makinen P, Dobson G, McDougall G . Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease. J Nutr Biochem. 2012; 24(1):360-70. DOI: 10.1016/j.jnutbio.2012.07.006. View

16.

Rao J, Keleshian V, Klein S, Rapoport S . Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry. 2012; 2:e132. PMC: 3410632. DOI: 10.1038/tp.2012.55. View

17.

Peterson D, George R, Scaramozzino F, LaPointe N, Anderson R, Graves D . Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis. 2009; 17(3):585-97. DOI: 10.3233/JAD-2009-1083. View

18.

Boesch-Saadatmandi C, Wagner A, Wolffram S, Rimbach G . Effect of quercetin on inflammatory gene expression in mice liver in vivo - role of redox factor 1, miRNA-122 and miRNA-125b. Pharmacol Res. 2012; 65(5):523-30. DOI: 10.1016/j.phrs.2012.02.007. View

19.

Wang S, Oelze B, Schumacher A . Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One. 2008; 3(7):e2698. PMC: 2444024. DOI: 10.1371/journal.pone.0002698. View

20.

Coppede F . One-carbon metabolism and Alzheimer's disease: focus on epigenetics. Curr Genomics. 2010; 11(4):246-60. PMC: 2930664. DOI: 10.2174/138920210791233090. View