Compositional Dynamics of the Human Intestinal Microbiota with Aging: Implications for Health

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2014 Nov 13

PMID 25389954

Citations 28

Authors

B Lakshminarayanan

C Stanton

P W OToole

R P Ross

Affiliations

Soon will be listed here.

Abstract

The human gut contains trillions of microbes which form an essential part of the complex ecosystem of the host. This microbiota is relatively stable throughout adult life, but may fluctuate over time with aging and disease. The gut microbiota serves a number of functions including roles in energy provision, nutrition and also in the maintenance of host health such as protection against pathogens. This review summarizes the age-related changes in the microbiota of the gastrointestinal tract (GIT) and the link between the gut microbiota in health and disease. Understanding the composition and function of the gut microbiota along with the changes it undergoes overtime should aid the design of novel therapeutic strategies to counteract such alterations. These strategies include probiotic and prebiotic preparations as well as targeted nutrients, designed to enrich the gut microbiota of the aging population.

Citing Articles

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References

Wu G, Chen J, Hoffmann C, Bittinger K, Chen Y, Keilbaugh S . Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011; 334(6052):105-8. PMC: 3368382. DOI: 10.1126/science.1208344. View

Vaahtovuo J, Munukka E, Korkeamaki M, Luukkainen R, Toivanen P . Fecal microbiota in early rheumatoid arthritis. J Rheumatol. 2008; 35(8):1500-5. View

Tiihonen K, Tynkkynen S, Ouwehand A, Ahlroos T, Rautonen N . The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology. Br J Nutr. 2008; 100(1):130-7. DOI: 10.1017/S000711450888871X. View

Kruis W, Forstmaier G, Scheurlen C, Stellaard F . Effect of diets low and high in refined sugars on gut transit, bile acid metabolism, and bacterial fermentation. Gut. 1991; 32(4):367-71. PMC: 1379072. DOI: 10.1136/gut.32.4.367. View

Hawrelak J, Myers S . The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004; 9(2):180-97. View

Malaguarnera L, Cristaldi E, Malaguarnera M . The role of immunity in elderly cancer. Crit Rev Oncol Hematol. 2009; 74(1):40-60. DOI: 10.1016/j.critrevonc.2009.06.002. View

Villareal D, Apovian C, Kushner R, Klein S . Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr. 2005; 82(5):923-34. DOI: 10.1093/ajcn/82.5.923. View

Dominguez-Bello M, Costello E, Contreras M, Magris M, Hidalgo G, Fierer N . Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010; 107(26):11971-5. PMC: 2900693. DOI: 10.1073/pnas.1002601107. View

Medellin-Pena M, Griffiths M . Effect of molecules secreted by Lactobacillus acidophilus strain La-5 on Escherichia coli O157:H7 colonization. Appl Environ Microbiol. 2008; 75(4):1165-72. PMC: 2643578. DOI: 10.1128/AEM.01651-08. View

10.

Penders J, Thijs C, Vink C, Stelma F, Snijders B, Kummeling I . Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006; 118(2):511-21. DOI: 10.1542/peds.2005-2824. View

11.

Smith M, Yatsunenko T, Manary M, Trehan I, Mkakosya R, Cheng J . Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013; 339(6119):548-54. PMC: 3667500. DOI: 10.1126/science.1229000. View

12.

Lahtinen S, Forssten S, Aakko J, Granlund L, Rautonen N, Salminen S . Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly. Age (Dordr). 2011; 34(1):133-43. PMC: 3260371. DOI: 10.1007/s11357-011-9208-6. View

13.

Sanz Y . Effects of a gluten-free diet on gut microbiota and immune function in healthy adult humans. Gut Microbes. 2011; 1(3):135-7. PMC: 3023594. DOI: 10.4161/gmic.1.3.11868. View

14.

Pappagallo M . Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2002; 182(5A Suppl):11S-18S. DOI: 10.1016/s0002-9610(01)00782-6. View

15.

Guillemard E, Tondu F, Lacoin F, Schrezenmeir J . Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2009; 103(1):58-68. DOI: 10.1017/S0007114509991395. View

16.

Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T . Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 2006; 72(2):1027-33. PMC: 1392899. DOI: 10.1128/AEM.72.2.1027-1033.2006. View

17.

Furrie E, Macfarlane S, Kennedy A, Cummings J, Walsh S, ONeil D . Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut. 2005; 54(2):242-9. PMC: 1774839. DOI: 10.1136/gut.2004.044834. View

18.

Ahmed M, Prasad J, Gill H, Stevenson L, Gopal P . Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging. 2007; 11(1):26-31. View

19.

Young V, Schmidt T . Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J Clin Microbiol. 2004; 42(3):1203-6. PMC: 356823. DOI: 10.1128/JCM.42.3.1203-1206.2004. View

20.

Woodmansey E . Intestinal bacteria and ageing. J Appl Microbiol. 2007; 102(5):1178-86. DOI: 10.1111/j.1365-2672.2007.03400.x. View