Innate Lymphoid Cells in the Skin

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2014 Oct 24

PMID 25339380

Citations 39

Authors

Brian S Kim

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions. Finally, we address how these studies have informed our understanding of the regulation of ILCs and the therapeutic potential of targeting these cells in the context of skin inflammation.

Citing Articles

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection.

To T, Oparaugo N, Kheshvadjian A, Nelson A, Agak G Int J Mol Sci. 2024; 25(4).

PMID: 38396697 PMC: 10888374. DOI: 10.3390/ijms25042021.

Innate lymphoid cells: a new key player in atopic dermatitis.

Jia H, Wan H, Zhang D Front Immunol. 2023; 14:1277120.

PMID: 37908364 PMC: 10613734. DOI: 10.3389/fimmu.2023.1277120.

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis.

Li J, Wang L, Yin S, Yu S, Zhou Y, Lin X CNS Neurosci Ther. 2023; 30(4):e14514.

PMID: 37902196 PMC: 11017449. DOI: 10.1111/cns.14514.

Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata.

Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A Elife. 2023; 12.

PMID: 36930216 PMC: 10023162. DOI: 10.7554/eLife.80768.

Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa.

Petrasca A, Hambly R, Molloy O, Kearns S, Moran B, Smith C PLoS One. 2023; 18(2):e0281688.

PMID: 36780439 PMC: 9924995. DOI: 10.1371/journal.pone.0281688.

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