Innate Lymphoid Cells: a New Key Player in Atopic Dermatitis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Nov 1

PMID 37908364

Authors

Haiping Jia

Huiying Wan

Dingding Zhang

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a common allergic inflammatory skin condition mainly caused by gene variants, immune disorders, and environmental risk factors. The T helper (Th) 2 immune response mediated by interleukin (IL)-4/13 is generally believed to be central in the pathogenesis of AD. It has been shown that innate lymphoid cells (ILCs) play a major effector cell role in the immune response in tissue homeostasis and inflammation and fascinating details about the interaction between innate and adaptive immunity. Changes in ILCs may contribute to the onset and progression of AD, and ILC2s especially have gained much attention. However, the role of ILCs in AD still needs to be further elucidated. This review summarizes the role of ILCs in skin homeostasis and highlights the signaling pathways in which ILCs may be involved in AD, thus providing valuable insights into the behavior of ILCs in skin homeostasis and inflammation, as well as new approaches to treating AD.

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References

Namkung J, Lee J, Kim E, Park G, Yang H, Jang H . An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population. J Dermatol Sci. 2011; 62(1):16-21. DOI: 10.1016/j.jdermsci.2011.01.007. View

Thammahong A, Kiatsurayanon C, Edwards S, Rerknimitr P, Chiewchengchol D . The clinical significance of fungi in atopic dermatitis. Int J Dermatol. 2020; 59(8):926-935. DOI: 10.1111/ijd.14941. View

Sun Z, Vattepu R, Zhang S . Chemokines and Innate Lymphoid Cells in Skin Inflammation. Cells. 2021; 10(11). PMC: 8621478. DOI: 10.3390/cells10113074. View

Kim M, Jin S, Jang S, Choi J, Chung D, Lee D . IL-17A-Producing Innate Lymphoid Cells Promote Skin Inflammation by Inducing IL-33-Driven Type 2 Immune Responses. J Invest Dermatol. 2019; 140(4):827-837.e9. DOI: 10.1016/j.jid.2019.08.447. View

Van den Bossche J, Van Ginderachter J . E-cadherin: from epithelial glue to immunological regulator. Eur J Immunol. 2012; 43(1):34-7. DOI: 10.1002/eji.201243168. View

Reynolds G, Vegh P, Fletcher J, Poyner E, Stephenson E, Goh I . Developmental cell programs are co-opted in inflammatory skin disease. Science. 2021; 371(6527). PMC: 7611557. DOI: 10.1126/science.aba6500. View

Zhong C, Zheng M, Zhu J . Lymphoid tissue inducer-A divergent member of the ILC family. Cytokine Growth Factor Rev. 2018; 42:5-12. PMC: 6089680. DOI: 10.1016/j.cytogfr.2018.02.004. View

Guttman-Yassky E, Brunner P, Neumann A, Khattri S, Pavel A, Malik K . Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial. J Am Acad Dermatol. 2018; 78(5):872-881.e6. PMC: 8711034. DOI: 10.1016/j.jaad.2018.01.016. View

Gupta K, Harvima I . Mast cell-neural interactions contribute to pain and itch. Immunol Rev. 2018; 282(1):168-187. PMC: 5812374. DOI: 10.1111/imr.12622. View

10.

Puya R, Alvarez-Lopez M, Velez A, Casas Asuncion E, Moreno J . Treatment of severe refractory adult atopic dermatitis with ustekinumab. Int J Dermatol. 2011; 51(1):115-6. DOI: 10.1111/j.1365-4632.2011.05195.x. View

11.

Borys S, Bag A, Brossay L, Adeegbe D . The Yin and Yang of Targeting KLRG1 Tregs and Effector Cells. Front Immunol. 2022; 13:894508. PMC: 9098823. DOI: 10.3389/fimmu.2022.894508. View

12.

van den Bogaard E, Bergboer J, Vonk-Bergers M, van Vlijmen-Willems I, Hato S, van der Valk P . Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. J Clin Invest. 2013; 123(2):917-27. PMC: 3561798. DOI: 10.1172/JCI65642. View

13.

Constantinides M, McDonald B, Verhoef P, Bendelac A . A committed precursor to innate lymphoid cells. Nature. 2014; 508(7496):397-401. PMC: 4003507. DOI: 10.1038/nature13047. View

14.

Vosshenrich C, Garcia-Ojeda M, Samson-Villeger S, Pasqualetto V, Enault L, Goff O . A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol. 2006; 7(11):1217-24. DOI: 10.1038/ni1395. View

15.

Nograles K, Zaba L, Shemer A, Fuentes-Duculan J, Cardinale I, Kikuchi T . IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells. J Allergy Clin Immunol. 2009; 123(6):1244-52.e2. PMC: 2874584. DOI: 10.1016/j.jaci.2009.03.041. View

16.

Walker J, Barlow J, McKenzie A . Innate lymphoid cells--how did we miss them?. Nat Rev Immunol. 2013; 13(2):75-87. DOI: 10.1038/nri3349. View

17.

Salimi M, Barlow J, Saunders S, Xue L, Gutowska-Owsiak D, Wang X . A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013; 210(13):2939-50. PMC: 3865470. DOI: 10.1084/jem.20130351. View

18.

Liu M, Liang S, Zhang C . NK Cells in Autoimmune Diseases: Protective or Pathogenic?. Front Immunol. 2021; 12:624687. PMC: 7994264. DOI: 10.3389/fimmu.2021.624687. View

19.

Egert M, Simmering R, Riedel C . The Association of the Skin Microbiota With Health, Immunity, and Disease. Clin Pharmacol Ther. 2017; 102(1):62-69. DOI: 10.1002/cpt.698. View

20.

Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A . Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014; 134(9):2351-2360. DOI: 10.1038/jid.2014.146. View