Hyperglycemia As a Risk Factor of Ischemic Stroke

Overview

Journal J Drug Metab Toxicol

Publisher Omics Publishing Group

Date 2014 Oct 21

PMID 25328819

Citations 20

Authors

Ziyan Zhang

Jingqi Yan

Honglian Shi

Affiliations

Soon will be listed here.

Abstract

Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.

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