Evolution of the Stroke Paradigm: A Review of Delayed Recanalization

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2020 Dec 16

PMID 33325765

Citations 8

Authors

Richard Camara

Nathanael Matei

John H Zhang

Affiliations

Soon will be listed here.

Abstract

While the time window for reperfusion after ischemic stroke continues to increase, many patients are not candidates for reperfusion under current guidelines that allow for reperfusion within 24 h after last known well time; however, many case studies report favorable outcomes beyond 24 h after symptom onset for both spontaneous and medically induced recanalization. Furthermore, modern imaging allows for identification of penumbra at extended time points, and reperfusion risk factors and complications are becoming better understood. Taken together, continued urgency exists to better understand the pathophysiologic mechanisms and ideal setting of delayed recanalization beyond 24 h after onset of ischemia.

Citing Articles

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Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats.

Li D, Lian L, Huang L, Gamdzyk M, Huang Y, Doycheva D Exp Neurol. 2023; 371:114607.

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Cold Case of Thrombolysis: Cold Recombinant Tissue Plasminogen Activator Confers Enhanced Neuroprotection in Experimental Stroke.

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Three Days Delayed Recanalization Improved Neurological Function in pMCAO Rats by Increasing M2 Microglia-Possible Involvement of the IL-4R/STAT6/PPARγ Pathway.

Kang R, Gamdzyk M, Luo Y, Tang H, Huang L, Lenahan C Transl Stroke Res. 2022; 14(2):250-262.

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Mechanical thrombectomy failure in anterior circulation strokes: Outcomes and predictors of favorable outcome.

Marnat G, Gory B, Sibon I, Kyheng M, Labreuche J, Boulouis G Eur J Neurol. 2022; 29(9):2701-2707.

PMID: 35648445 PMC: 9541042. DOI: 10.1111/ene.15429.

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