Impact of MicroRNAs on Ischemic Stroke: From Pre- to Post-disease

Overview

Journal Prog Neurobiol

Specialty Neurology

Date 2017 Aug 27

PMID 28842356

Citations 89

Authors

Guangwen Li

Kahlilia C Morris-Blanco

Mary S Lopez

Tuo Yang

Haiping Zhao

Raghu Vemuganti

Yumin Luo

Affiliations

Soon will be listed here.

Abstract

Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke. In this review, we compile miRNAs that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of miRNAs in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis. Since promoting or suppressing expression of miRNAs by specific pharmaceutical and non-pharmaceutical therapies may be beneficial to post-stroke recovery, we also highlight the potential therapeutic value of miRNAs in clinical settings.

Citing Articles

Role of microRNA in the risk stratification of ischemic strokes.

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The miR-451a facilitates natural killer cell-associated immune deficiency after ischemic stroke.

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Sex and Age-Dependent Effects of miR-15a/16-1 Antagomir on Ischemic Stroke Outcomes.

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