The Complex Portal--an Encyclopaedia of Macromolecular Complexes

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2014 Oct 15

PMID 25313161

Citations 51

Authors

Birgit H M Meldal

Oscar Forner-Martinez

Maria C Costanzo

Jose Dana

Janos Demeter

Marine Dumousseau

Selina S Dwight

Anna Gaulton

Luana Licata

Anna N Melidoni

Sylvie Ricard-Blum

Bernd Roechert

Marek S Skyzypek

Manu Tiwari

Sameer Velankar

Edith D Wong

Henning Hermjakob

Sandra Orchard

Affiliations

Soon will be listed here.

Abstract

The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniProtKB. Each entry contains information about the participating molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. Input from groups and individuals with specific areas of expertise is welcome.

Citing Articles

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