» Articles » PMID: 25231980

Glycine Induces Bidirectional Modifications in N-methyl-D-aspartate Receptor-mediated Synaptic Responses in Hippocampal CA1 Neurons

Overview
Journal J Biol Chem
Specialty Biochemistry
Date 2014 Sep 19
PMID 25231980
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Glycine can persistently potentiate or depress AMPA responses through differential actions on two binding sites: NMDA and glycine receptors. Whether glycine can induce long-lasting modifications in NMDA responses, however, remains unknown. Here, we report that glycine induces long-term potentiation (LTP) or long-term depression (LTD) of NMDA responses (Gly-LTP(NMDA) or Gly-LTD(NMDA)) in a dose-dependent manner in hippocampal CA1 neurons. These modifications of NMDA responses depend on NMDAR activation. In addition, the induction of Gly-LTP(NMDA) requires binding of glycine with NMDARs, whereas Gly-LTD(NMDA) requires that glycine bind with both sites on NMDARs and GlyRs. Moreover, activity-dependent exocytosis and endocytosis of postsynaptic NMDARs underlie glycine-induced bidirectional modification of NMDA excitatory postsynaptic currents. Thus, we conclude that glycine at different levels induces bidirectional plasticity of NMDA responses through differentially regulating NMDA receptor trafficking. Our present findings reveal important functions of the two glycine binding sites in gating the direction of synaptic plasticity in NMDA responses.

Citing Articles

Dendritic Spines of Layer 5 Pyramidal Neurons of the Aging Somatosensory Cortex Exhibit Reduced Volumetric Remodeling.

Ducote A, Voglewede R, Mostany R J Neurosci. 2024; 44(50).

PMID: 39448263 PMC: 11638818. DOI: 10.1523/JNEUROSCI.1378-24.2024.


Molecular mechanisms underlying sex and treatment-dependent differences in an animal model of cue-exposure therapy for cocaine relapse prevention.

Peterson L, Nguyen J, Ghani N, Rodriguez-Echemendia P, Qiao H, Guwn S Front Neurosci. 2024; 18:1425447.

PMID: 39176383 PMC: 11339646. DOI: 10.3389/fnins.2024.1425447.


Glutamatergic Modulators for Major Depression from Theory to Clinical Use.

McIntyre R, Jain R CNS Drugs. 2024; 38(11):869-890.

PMID: 39150594 PMC: 11486832. DOI: 10.1007/s40263-024-01114-y.


Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats.

Lu K, Zhao L, Zhang Y, Yang F, Zhang H, Wang J Sci Rep. 2022; 12(1):1378.

PMID: 35082359 PMC: 8792009. DOI: 10.1038/s41598-022-05478-3.


FORTIS: a live-cell assay to monitor AMPA receptors using pH-sensitive fluorescence tags.

Calleja-Felipe M, Wojtas M, Diaz-Gonzalez M, Ciceri D, Escribano R, Ouro A Transl Psychiatry. 2021; 11(1):324.

PMID: 34045447 PMC: 8160262. DOI: 10.1038/s41398-021-01457-w.


References
1.
Chen R, Wang S, Yao W, Wang J, Ji F, Yan J . Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons. Neuropsychopharmacology. 2011; 36(9):1948-58. PMC: 3154115. DOI: 10.1038/npp.2011.86. View

2.
Yuan T, Bellone C . Glutamatergic receptors at developing synapses: the role of GluN3A-containing NMDA receptors and GluA2-lacking AMPA receptors. Eur J Pharmacol. 2013; 719(1-3):107-111. DOI: 10.1016/j.ejphar.2013.04.056. View

3.
Caputi A, Gardoni F, Cimino M, Pastorino L, Cattabeni F, Di Luca M . CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP. Eur J Neurosci. 1999; 11(1):141-8. DOI: 10.1046/j.1460-9568.1999.00414.x. View

4.
Kemp J, Leeson P . The glycine site of the NMDA receptor--five years on. Trends Pharmacol Sci. 1993; 14(1):20-5. DOI: 10.1016/0165-6147(93)90108-v. View

5.
Morishita W, Marie H, Malenka R . Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat Neurosci. 2005; 8(8):1043-50. DOI: 10.1038/nn1506. View