MicroRNAs in Respiratory Disease. A Clinician's Overview

Overview

Journal Ann Am Thorac Soc

Specialty Pulmonary Medicine

Date 2014 Aug 31

PMID 25172373

Citations 24

Authors

Derek Brown

Mohammad Rahman

S Patrick Nana-Sinkam

Affiliations

Soon will be listed here.

Abstract

Since their initial discovery in the early 1990s, microRNAs have now become the focus of a multitude of lines of investigation ranging from basic biology to translational applications in the clinic. Previously believed to be of no biological relevance, microRNAs regulate processes fundamental to human health and disease. In diseases of the lung, microRNAs have been implicated in developmental programming, as drivers of disease, potential therapeutic targets, and clinical biomarkers; however, several obstacles must be overcome for us to fully realize their potential therapeutic use. Here, we provide for the clinician an overview of microRNA biology in selected diseases of the lung with a focus on their potential clinical application.

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