The Role of MiRNAs in Alveolar Epithelial Cells in Emphysema

Overview

Journal Biomed Pharmacother

Specialties Biology
General Medicine
Pharmacology

Date 2021 Oct 15

PMID 34649347

Citations 11

Authors

Hassan Hayek

Beata Kosmider

Karim Bahmed

Affiliations

Soon will be listed here.

Abstract

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease becoming one of the leading causes of mortality and morbidity globally. The significant risk factors for COPD are exposure to harmful particles such as cigarette smoke, biomass smoke, and air pollution. Pulmonary emphysema belongs to COPD and is characterized by a unique alveolar destruction pattern resulting in marked airspace enlargement. Alveolar type II (ATII) cells have stem cell potential; they proliferate and differentiate to alveolar type I cells to restore the epithelium after damage. Oxidative stress causes premature cell senescence that can contribute to emphysema development. MiRNAs regulate gene expression, are essential for maintaining ATII cell homeostasis, and their dysregulation contributes to this disease development. They also serve as biomarkers of lung diseases and potential therapeutics. In this review, we summarize recent findings on miRNAs' role in alveolar epithelial cells in emphysema.

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