MicroRNAs in Kidney Transplantation

Overview

Journal Nephrol Dial Transplant

Publisher Oxford University Press

Specialties General Surgery
Nephrology

Date 2014 Aug 30

PMID 25170095

Citations 16

Authors

Julia Wilflingseder

Roman Reindl-Schwaighofer

Judith Sunzenauer

Alexander Kainz

Andreas Heinzel

Bernd Mayer

Rainer Oberbauer

Affiliations

Soon will be listed here.

Abstract

The discovery of novel classes of non-coding RNAs (ncRNAs) has revolutionized medicine. Long thought to be a mere cellular housekeeper, surprising functions have recently been uncovered. MicroRNAs (miRNAs), are a representative of the class of short ncRNAs, play a fundamental role in the control of DNA and protein biosynthesis and activity as well as pathology. Currently, miRNAs are being investigated as diagnostic and prognostic markers and potential therapeutic targets in kidney transplantation for such indolent processes as ischaemia-reperfusion injury, humoral rejection or viral infections. It is realistic to believe that monitoring of renal allograft recipients in the future will include genome-wide miRNA profiling of biological fluids. Based on these individual profiles, an informed decision on therapeutic consequences will be possible. A first success with a specific suppression of miRNAs by antisense oligonucleotides was achieved in experimental studies of reperfusion injury and humoral rejection. Proof of this concept in men comes from studies in such indolent viral infections as Ebola and hepatitis C, where anti-miR therapy led to sustained viral clearance. In this review, we summarize the basis of the recent ncRNA revolution and its implication for kidney transplantation.

Citing Articles

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References

Friedman R, Farh K, Burge C, Bartel D . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2008; 19(1):92-105. PMC: 2612969. DOI: 10.1101/gr.082701.108. View

Chi S, Zang J, Mele A, Darnell R . Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009; 460(7254):479-86. PMC: 2733940. DOI: 10.1038/nature08170. View

Ramachandran K, Saikumar J, Bijol V, Koyner J, Qian J, Betensky R . Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury. Clin Chem. 2013; 59(12):1742-52. PMC: 3870155. DOI: 10.1373/clinchem.2013.210245. View

Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391(6669):806-11. DOI: 10.1038/35888. View

Sallustio F, Serino G, Costantino V, Curci C, Cox S, De Palma G . miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. PLoS One. 2013; 8(7):e68296. PMC: 3704645. DOI: 10.1371/journal.pone.0068296. View

Sui W, Lin H, Peng W, Huang Y, Chen J, Zhang Y . Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA. Genomics. 2013; 102(4):310-22. DOI: 10.1016/j.ygeno.2013.05.002. View

Amrouche L, Rabant M, Anglicheau D . MicroRNAs as biomarkers of graft outcome. Transplant Rev (Orlando). 2014; 28(3):111-8. DOI: 10.1016/j.trre.2014.03.003. View

Ambros V, Bartel B, Bartel D, Burge C, Carrington J, Chen X . A uniform system for microRNA annotation. RNA. 2003; 9(3):277-9. PMC: 1370393. DOI: 10.1261/rna.2183803. View

Lee E, Baek M, Gusev Y, Brackett D, Nuovo G, Schmittgen T . Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA. 2007; 14(1):35-42. PMC: 2151027. DOI: 10.1261/rna.804508. View

10.

Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T . Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell. 2004; 15(2):185-97. DOI: 10.1016/j.molcel.2004.07.007. View

11.

Dolken L, Pfeffer S, Koszinowski U . Cytomegalovirus microRNAs. Virus Genes. 2009; 38(3):355-64. DOI: 10.1007/s11262-009-0347-0. View

12.

Halloran P, Reeve J, Pereira A, Hidalgo L, Famulski K . Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies. Kidney Int. 2013; 85(2):258-64. DOI: 10.1038/ki.2013.300. View

13.

Tay Y, Rinn J, Pandolfi P . The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014; 505(7483):344-52. PMC: 4113481. DOI: 10.1038/nature12986. View

14.

Reinhart B, Slack F, Basson M, Pasquinelli A, Bettinger J, Rougvie A . The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000; 403(6772):901-6. DOI: 10.1038/35002607. View

15.

Danger R, Paul C, Giral M, Lavault A, Foucher Y, Degauque N . Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection. PLoS One. 2013; 8(4):e60702. PMC: 3618046. DOI: 10.1371/journal.pone.0060702. View

16.

Dweep H, Sticht C, Pandey P, Gretz N . miRWalk--database: prediction of possible miRNA binding sites by "walking" the genes of three genomes. J Biomed Inform. 2011; 44(5):839-47. DOI: 10.1016/j.jbi.2011.05.002. View

17.

Fukuhara T, Kambara H, Shiokawa M, Ono C, Katoh H, Morita E . Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus. J Virol. 2012; 86(15):7918-33. PMC: 3421686. DOI: 10.1128/JVI.00567-12. View

18.

Wilflingseder J, Sunzenauer J, Toronyi E, Heinzel A, Kainz A, Mayer B . Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles. PLoS One. 2014; 9(8):e104164. PMC: 4122455. DOI: 10.1371/journal.pone.0104164. View

19.

Wilflingseder J, Regele H, Perco P, Kainz A, Soleiman A, Muhlbacher F . miRNA profiling discriminates types of rejection and injury in human renal allografts. Transplantation. 2013; 95(6):835-41. PMC: 3677100. DOI: 10.1097/TP.0b013e318280b385. View

20.

Van Rooij E . The art of microRNA research. Circ Res. 2011; 108(2):219-34. DOI: 10.1161/CIRCRESAHA.110.227496. View