MiR-152 Suppresses Gastric Cancer Cell Proliferation and Motility by Targeting CD151

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2014 Aug 15

PMID 25119599

Citations 26

Authors

Ronglin Zhai

Xuefeng Kan

Bo Wang

Hansong Du

Yueping Long

Heshui Wu

Kaixiong Tao

Guobin Wang

Lihong Bao

Fen Li

Wanli Zhang

Affiliations

Soon will be listed here.

Abstract

We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.

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