Novel Flaviviruses from Mosquitoes: Mosquito-specific Evolutionary Lineages Within the Phylogenetic Group of Mosquito-borne Flaviviruses

Overview

Journal Virology

Specialty Microbiology

Date 2014 Aug 11

PMID 25108382

Citations 36

Authors

Eili Huhtamo

Shelley Cook

Gregory Moureau

Nathalie Y Uzcategui

Tarja Sironen

Suvi Kuivanen

Niina Putkuri

Satu Kurkela

Ralph E Harbach

Andrew E Firth

Olli Vapalahti

Ernest A Gould

Xavier de Lamballerie

Affiliations

Soon will be listed here.

Abstract

Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector-borne transmission require further characterization. The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector-borne flaviviruses.

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References

Junglen S, Kopp A, Kurth A, Pauli G, Ellerbrok H, Leendertz F . A new flavivirus and a new vector: characterization of a novel flavivirus isolated from uranotaenia mosquitoes from a tropical rain forest. J Virol. 2009; 83(9):4462-8. PMC: 2668441. DOI: 10.1128/JVI.00014-09. View

Gaunt M, Gould E . Rapid subgroup identification of the flaviviruses using degenerate primer E-gene RT-PCR and site specific restriction enzyme analysis. J Virol Methods. 2005; 128(1-2):113-27. DOI: 10.1016/j.jviromet.2005.04.006. View

Stollar V, Thomas V . An agent in the Aedes aegypti cell line (Peleg) which causes fusion of Aedes albopictus cells. Virology. 1975; 64(2):367-77. DOI: 10.1016/0042-6822(75)90113-0. View

Cook S, Holmes E . A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission. Arch Virol. 2005; 151(2):309-25. DOI: 10.1007/s00705-005-0626-6. View

Chappell K, Stoermer M, Fairlie D, Young P . Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. J Gen Virol. 2008; 89(Pt 4):1010-1014. DOI: 10.1099/vir.0.83447-0. View

Evangelista J, Cruz C, Guevara C, Astete H, Carey C, Kochel T . Characterization of a novel flavivirus isolated from Culex (Melanoconion) ocossa mosquitoes from Iquitos, Peru. J Gen Virol. 2013; 94(Pt 6):1266-1272. DOI: 10.1099/vir.0.050575-0. View

Firth A, Wills N, Gesteland R, Atkins J . Stimulation of stop codon readthrough: frequent presence of an extended 3' RNA structural element. Nucleic Acids Res. 2011; 39(15):6679-91. PMC: 3159437. DOI: 10.1093/nar/gkr224. View

Grard G, Moureau G, Charrel R, Holmes E, Gould E, de Lamballerie X . Genomics and evolution of Aedes-borne flaviviruses. J Gen Virol. 2009; 91(Pt 1):87-94. DOI: 10.1099/vir.0.014506-0. View

Morales-Betoulle M, Monzon Pineda M, Sosa S, Panella N, Lopez M, Cordon-Rosales C . Culex flavivirus isolates from mosquitoes in Guatemala. J Med Entomol. 2008; 45(6):1187-90. DOI: 10.1603/0022-2585(2008)45[1187:cfifmi]2.0.co;2. View

10.

Castresana J . Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol. 2000; 17(4):540-52. DOI: 10.1093/oxfordjournals.molbev.a026334. View

11.

Scaramozzino N, Crance J, Jouan A, DeBriel D, Stoll F, Garin D . Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol. 2001; 39(5):1922-7. PMC: 88049. DOI: 10.1128/JCM.39.5.1922-1927.2001. View

12.

Gould E, Buckley A, Cammack N, Barrett A, Clegg J, Ishak R . Examination of the immunological relationships between flaviviruses using yellow fever virus monoclonal antibodies. J Gen Virol. 1985; 66 ( Pt 7):1369-82. DOI: 10.1099/0022-1317-66-7-1369. View

13.

Grard G, Moureau G, Charrel R, Lemasson J, Gonzalez J, Gallian P . Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy. Virology. 2006; 361(1):80-92. DOI: 10.1016/j.virol.2006.09.015. View

14.

Cook S, Bennett S, Holmes E, de Chesse R, Moureau G, de Lamballerie X . Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico. J Gen Virol. 2006; 87(Pt 4):735-748. DOI: 10.1099/vir.0.81475-0. View

15.

Kolodziejek J, Pachler K, Bin H, Mendelson E, Shulman L, Orshan L . Barkedji virus, a novel mosquito-borne flavivirus identified in Culex perexiguus mosquitoes, Israel, 2011. J Gen Virol. 2013; 94(Pt 11):2449-2457. DOI: 10.1099/vir.0.056200-0. View

16.

Huhtamo E, Moureau G, Cook S, Julkunen O, Putkuri N, Kurkela S . Novel insect-specific flavivirus isolated from northern Europe. Virology. 2012; 433(2):471-8. PMC: 3919202. DOI: 10.1016/j.virol.2012.08.038. View

17.

Kuno G . Host range specificity of flaviviruses: correlation with in vitro replication. J Med Entomol. 2007; 44(1):93-101. DOI: 10.1603/0022-2585(2007)44[93:hrsofc]2.0.co;2. View

18.

Emonet S, Grard G, Brisbarre N, Moureau G, Temmam S, Charrel R . Long PCR Product Sequencing (LoPPS): a shotgun-based approach to sequence long PCR products. Nat Protoc. 2007; 2(2):340-6. DOI: 10.1038/nprot.2006.453. View

19.

Cook S, Moureau G, Kitchen A, Gould E, de Lamballerie X, Holmes E . Molecular evolution of the insect-specific flaviviruses. J Gen Virol. 2011; 93(Pt 2):223-234. PMC: 3352342. DOI: 10.1099/vir.0.036525-0. View

20.

Firth A, Blitvich B, Wills N, Miller C, Atkins J . Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses. Virology. 2010; 399(1):153-166. PMC: 2830293. DOI: 10.1016/j.virol.2009.12.033. View