Topical Photodynamic Therapy Induces Systemic Immunosuppression Via Generation of Platelet-activating Factor Receptor Ligands

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2014 Jul 23

PMID 25050596

Citations 16

Authors

Matheus Ferracini

Ravi P Sahu

Kathleen A Harrison

Robert A Waeiss

Robert C Murphy

Sonia Jancar

Raymond L Konger

Jeffrey B Travers

Affiliations

Soon will be listed here.

Citing Articles

Topical Photodynamic Therapy Generates Bioactive Microvesicle Particles: Evidence for a Pathway Involved in Immunosuppressive Effects.

Oyebanji O, Brewer C, Bayless S, Schmeusser B, Corbin D, Sulentic C J Invest Dermatol. 2023; 143(7):1279-1288.e9.

PMID: 36708950 PMC: 10293022. DOI: 10.1016/j.jid.2022.12.018.

Implications of Aspirin for Melanoma Treatment: A Short Perspective.

Thyagarajan A, Sahu R J Mol Genet Med (Lond). 2021; 1(1).

PMID: 34927173 PMC: 8681500.

Inhibition of photodynamic therapy induced-immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre-cancerous lesions.

Bayless S, Travers J, Sahu R, Rohan C Oncol Lett. 2021; 22(3):664.

PMID: 34386086 PMC: 8298988. DOI: 10.3892/ol.2021.12925.

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients.

Ke M, Kang L, Wang L, Yang S, Wang Y, Liu H J Hematol Oncol. 2021; 14(1):90.

PMID: 34108020 PMC: 8191024. DOI: 10.1186/s13045-021-01101-6.

Platelet-Activating Factor as an Effector for Environmental Stressors.

Travers J Handb Exp Pharmacol. 2019; 259:185-203.

PMID: 31087194 PMC: 7112171. DOI: 10.1007/164_2019_218.

References

Sahu R, Turner M, DaSilva S, Rashid B, Ocana J, Perkins S . The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis. 2012; 33(7):1360-7. PMC: 3405652. DOI: 10.1093/carcin/bgs152. View

Konger R, Marathe G, Yao Y, Zhang Q, Travers J . Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. Prostaglandins Other Lipid Mediat. 2008; 87(1-4):1-8. PMC: 3343742. DOI: 10.1016/j.prostaglandins.2008.04.002. View

Mroz P, Hamblin M . The immunosuppressive side of PDT. Photochem Photobiol Sci. 2011; 10(5):751-8. PMC: 3441049. DOI: 10.1039/c0pp00345j. View

Dougherty T, Gomer C, Henderson B, Jori G, Kessel D, Korbelik M . Photodynamic therapy. J Natl Cancer Inst. 1998; 90(12):889-905. PMC: 4592754. DOI: 10.1093/jnci/90.12.889. View

Zhang Q, Yao Y, Konger R, Sinn A, Cai S, Pollok K . UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. J Invest Dermatol. 2008; 128(7):1780-7. PMC: 2643301. DOI: 10.1038/sj.jid.5701251. View

Morton C, McKenna K, Rhodes L . Guidelines for topical photodynamic therapy: update. Br J Dermatol. 2008; 159(6):1245-66. DOI: 10.1111/j.1365-2133.2008.08882.x. View

Wolf P, Nghiem D, Walterscheid J, Byrne S, Matsumura Y, Matsumura Y . Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. Am J Pathol. 2006; 169(3):795-805. PMC: 1579250. DOI: 10.2353/ajpath.2006.060079. View

Walterscheid J, Ullrich S, Nghiem D . Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med. 2002; 195(2):171-9. PMC: 2193612. DOI: 10.1084/jem.20011450. View

Matthews Y, Damian D . Topical photodynamic therapy is immunosuppressive in humans. Br J Dermatol. 2009; 162(3):637-41. DOI: 10.1111/j.1365-2133.2009.09562.x. View

10.

Yao Y, Harrison K, Al-Hassani M, Murphy R, Rezania S, Konger R . Platelet-activating factor receptor agonists mediate xeroderma pigmentosum A photosensitivity. J Biol Chem. 2012; 287(12):9311-21. PMC: 3308814. DOI: 10.1074/jbc.M111.332395. View

11.

Hayami J, Okamoto H, Sugihara A, Horio T . Immunosuppressive effects of photodynamic therapy by topical aminolevulinic acid. J Dermatol. 2007; 34(5):320-7. DOI: 10.1111/j.1346-8138.2007.00280.x. View

12.

Bachi A, Dos Santos L, Nonogaki S, Jancar S, Jasiulionis M . Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. Mediators Inflamm. 2012; 2012:610371. PMC: 3346991. DOI: 10.1155/2012/610371. View

13.

Yao Y, Wolverton J, Zhang Q, Marathe G, Al-Hassani M, Konger R . Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. J Immunol. 2009; 182(5):2842-8. PMC: 2750830. DOI: 10.4049/jimmunol.0802689. View

14.

Sahu R, Petrache I, Van Demark M, Rashid B, Ocana J, Tang Y . Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. J Immunol. 2013; 190(5):2447-54. PMC: 3577966. DOI: 10.4049/jimmunol.1202699. View

15.

Pei Y, Barber L, Murphy R, Johnson C, Kelley S, Dy L . Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. J Immunol. 1998; 161(4):1954-61. View