Novel Rearrangements at the Immunoglobulin D Locus. Inversions and Fusions Add to IgH Somatic Diversity

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1989 Jul 1

PMID 2501448

Citations 31

Authors

K D Meek

C A Hasemann

J D Capra

Affiliations

Soon will be listed here.

Abstract

IgH rearrangements (VH-D, D-JH) are central to the generation of antibody diversity. The majority of the diversity seen in the third hypervariable region is generated by the D segment and at the joints formed by both junctional and N segment variation during D-JH and VH-D rearrangements. The mechanisms that regulate rearrangement are thought to obey the 12/23 rule, wherein D-D or VH-JH rearrangements are precluded. Here, we present evidence that D-D fusions do in fact occur, either as direct or inverted rearrangements. The fused D segments so generated may be fully capable of proceeding in subsequent D-JH and VH-D rearrangements. The resultant VH-D-D-JH recombinations add another dimension to the potential repertoire of IgH V regions by increasing the level of combinatorial diversity and by providing additional sites for N region variation.

Citing Articles

Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity.

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Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications.

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