Structure of the Type IX Group B Streptococcus Capsular Polysaccharide and Its Evolutionary Relationship with Types V and VII

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2014 Jul 4

PMID 24990951

Citations 29

Authors

Francesco Berti

Edmondo Campisi

Chiara Toniolo

Laura Morelli

Stefano Crotti

Roberto Rosini

Maria Rosaria Romano

Vittoria Pinto

Barbara Brogioni

Giulia Torricelli

Robert Janulczyk

Guido Grandi

Immaculada Margarit

Affiliations

Soon will be listed here.

Abstract

The Group B Streptococcus capsular polysaccharide type IX was isolated and purified, and the structure of its repeating unit was determined. Type IX capsule → 4)[NeupNAc-α-(2 → 3)-Galp-β-(1 → 4)-GlcpNAc-β-(1 → 6)]-β-GlcpNAc-(1 → 4)-β-Galp-(1 → 4)-β-Glcp-(1 → appears most similar to types VII and V, although it contains two GlcpNAc residues. Genetic analysis identified differences in cpsM, cpsO, and cpsI gene sequences as responsible for the differentiation between the three capsular polysaccharide types, leading us to hypothesize that type V emerged from a recombination event in a type IX background.

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