Fabrication of Corona-free Nanoparticles with Tunable Hydrophobicity

Overview

Journal ACS Nano

Publisher American Chemical Society

Specialty Biotechnology

Date 2014 Jun 28

PMID 24971670

Citations 88

Authors

Daniel F Moyano

Krishnendu Saha

Gyan Prakash

Bo Yan

Hao Kong

Mahdieh Yazdani

Vincent M Rotello

Affiliations

Soon will be listed here.

Abstract

A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.

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