Fluorine-modified Polymers Reduce the Adsorption of Immune-reactive Proteins to PEGylated Gold Nanoparticles

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2024 Apr 9

PMID 38593053

Authors

Helen Forgham

Jiayuan Zhu

Taoran Zhang

Xumin Huang

Xiangke Li

Ao Shen

Heather Biggs

Gert Talbo

Chun Xu

Thomas P Davis

Ruirui Qiao

Affiliations

Soon will be listed here.

Abstract

To investigate the influence of fluorine in reducing the adsorption of immune-reactive proteins onto PEGylated gold nanoparticles. Reversible addition fragmentation chain transfer polymerization, the Turkevich method and ligand exchange were used to prepare polymer-coated gold nanoparticles. Subsequent physicochemical and biological characterizations and proteomic analysis were performed. Fluorine-modified polymers reduced the adsorption of complement and other immune-reactive proteins while potentially improving circulatory times and modulating liver toxicity by reducing apolipoprotein E adsorption. Fluorine actively discouraged phagocytosis while encouraging the adsorption of therapeutic targets, CD209 and signaling molecule calreticulin. This study suggests that the addition of fluorine in the surface coating of nanoparticles could lead to improved performance in nanomedicine designed for the intravenous delivery of cargos.

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