Inorganic Nanoparticles As Scaffolds for Bioorthogonal Catalysts

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2023 Feb 15

PMID 36791809

Authors

Cristina-Maria Hirschbiegel

Xianzhi Zhang

Rui Huang

Yagiz Anil Cicek

Stefano Fedeli

Vincent M Rotello

Affiliations

Soon will be listed here.

Abstract

Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules (pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize catalysts while offering a flexible design space for decoration with targeting elements and stimuli-responsive activity. These "drug factories" can activate pro-drugs in situ, localizing treatment to the disease site and minimizing off-target effects. Inorganic nanoscaffolds provide structurally diverse scaffolds for encapsulating TMCs. This ability to define the catalyst environment can be employed to enhance the stability and selectivity of the TMC, providing access to enzyme-like bioorthogonal processes. The use of inorganic nanomaterials as scaffolds TMCs and the use of these bioorthogonal nanozymes in vitro and in vivo applications will be discussed in this review.

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References

Huang H, Barua S, Sharma G, Dey S, Rege K . Inorganic nanoparticles for cancer imaging and therapy. J Control Release. 2011; 155(3):344-57. DOI: 10.1016/j.jconrel.2011.06.004. View

Alexiou C, Arnold W, Klein R, Parak F, Hulin P, Bergemann C . Locoregional cancer treatment with magnetic drug targeting. Cancer Res. 2000; 60(23):6641-8. View

McGuire C, Forgan R . The surface chemistry of metal-organic frameworks. Chem Commun (Camb). 2014; 51(25):5199-217. DOI: 10.1039/c4cc04458d. View

Drache F, Bon V, Senkovska I, Marschelke C, Synytska A, Kaskel S . Postsynthetic Inner-Surface Functionalization of the Highly Stable Zirconium-Based Metal-Organic Framework DUT-67. Inorg Chem. 2016; 55(15):7206-13. DOI: 10.1021/acs.inorgchem.6b00829. View

Di Nunzio M, Agostoni V, Cohen B, Gref R, Douhal A . A "ship in a bottle" strategy to load a hydrophilic anticancer drug in porous metal organic framework nanoparticles: efficient encapsulation, matrix stabilization, and photodelivery. J Med Chem. 2013; 57(2):411-20. DOI: 10.1021/jm4017202. View

Nam J, Son S, Ochyl L, Kuai R, Schwendeman A, Moon J . Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Commun. 2018; 9(1):1074. PMC: 5852008. DOI: 10.1038/s41467-018-03473-9. View

Nunez C, Estevez S, Del Pilar Chantada M . Inorganic nanoparticles in diagnosis and treatment of breast cancer. J Biol Inorg Chem. 2018; 23(3):331-345. DOI: 10.1007/s00775-018-1542-z. View

Horcajada P, Serre C, Vallet-Regi M, Sebban M, Taulelle F, Ferey G . Metal-organic frameworks as efficient materials for drug delivery. Angew Chem Int Ed Engl. 2006; 45(36):5974-8. DOI: 10.1002/anie.200601878. View

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

10.

Filep J . Targeting Neutrophils for Promoting the Resolution of Inflammation. Front Immunol. 2022; 13:866747. PMC: 8966391. DOI: 10.3389/fimmu.2022.866747. View

11.

Cai M, Chen G, Qin L, Qu C, Dong X, Ni J . Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer. Pharmaceutics. 2020; 12(3). PMC: 7150757. DOI: 10.3390/pharmaceutics12030232. View

12.

Han G, Ghosh P, Rotello V . Functionalized gold nanoparticles for drug delivery. Nanomedicine (Lond). 2007; 2(1):113-23. DOI: 10.2217/17435889.2.1.113. View

13.

Raj S, Khurana S, Choudhari R, Kesari K, Kamal M, Garg N . Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Semin Cancer Biol. 2019; 69:166-177. DOI: 10.1016/j.semcancer.2019.11.002. View

14.

Chen H, Lin W, Yuan L . Construction of a near-infrared fluorescence turn-on and ratiometric probe for imaging palladium in living cells. Org Biomol Chem. 2013; 11(12):1938-41. DOI: 10.1039/c3ob27507h. View

15.

Ling D, Lee N, Hyeon T . Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. Acc Chem Res. 2015; 48(5):1276-85. DOI: 10.1021/acs.accounts.5b00038. View

16.

Soundararajan S, Wang L, Sridharan V, Chen W, Courtenay-Luck N, Jones D . Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells. Mol Pharmacol. 2009; 76(5):984-91. PMC: 2774992. DOI: 10.1124/mol.109.055947. View

17.

Chen X, Cai W, Liu J, Mao L, Wang M . Integration of Palladium Nanoparticles with Surface Engineered Metal-Organic Frameworks for Cell-Selective Bioorthogonal Catalysis and Protein Activity Regulation. ACS Appl Mater Interfaces. 2022; 14(8):10117-10124. DOI: 10.1021/acsami.1c23213. View

18.

Singh L, Bhattacharyya S, Kumar R, Mishra G, Sharma U, Singh G . Sol-Gel processing of silica nanoparticles and their applications. Adv Colloid Interface Sci. 2014; 214:17-37. DOI: 10.1016/j.cis.2014.10.007. View

19.

Roy S, Deo K, Singh K, Lee H, Jaiswal A, Gaharwar A . Nano-bio interactions of 2D molybdenum disulfide. Adv Drug Deliv Rev. 2022; 187:114361. DOI: 10.1016/j.addr.2022.114361. View

20.

Aliakbari F, Haji Hosseinali S, Khalili Sarokhalil Z, Shahpasand K, Saboury A, Akhtari K . Reactive oxygen species generated by titanium oxide nanoparticles stimulate the hemoglobin denaturation and cytotoxicity against human lymphocyte cell. J Biomol Struct Dyn. 2019; 37(18):4875-4881. DOI: 10.1080/07391102.2019.1568305. View