Rational Design of Biotinylated Probes: Fluorescent Turn-on Detection of (strept)avidin and Bioimaging in Cancer Cells

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Jun 21

PMID 24948217

Citations 4

Authors

Qian Sun

Junhong Qian

Haiyu Tian

Liping Duan

Weibing Zhang

Affiliations

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Abstract

Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.

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