Genome-wide Association Analysis Demonstrates the Highly Polygenic Character of Age-related Hearing Impairment

Overview

Journal Eur J Hum Genet

Specialty Genetics

Date 2014 Jun 19

PMID 24939585

Citations 47

Authors

Erik Fransen

Sarah Bonneux

Jason J Corneveaux

Isabelle Schrauwen

Federica Di Berardino

Cory H White

Jeffrey D Ohmen

Paul Van de Heyning

Umberto Ambrosetti

Matthew J Huentelman

Guy Van Camp

Rick A Friedman

Affiliations

Soon will be listed here.

Abstract

We performed a genome-wide association study (GWAS) to identify the genes responsible for age-related hearing impairment (ARHI), the most common form of hearing impairment in the elderly. Analysis of common variants, with and without adjustment for stratification and environmental covariates, rare variants and interactions, as well as gene-set enrichment analysis, showed no variants with genome-wide significance. No evidence for replication of any previously reported genes was found. A study of the genetic architecture indicates for the first time that ARHI is highly polygenic in nature, with probably no major genes involved. The phenotype depends on the aggregated effect of a large number of SNPs, of which the individual effects are undetectable in a modestly powered GWAS. We estimated that 22% of the variance in our data set can be explained by the collective effect of all genotyped SNPs. A score analysis showed a modest enrichment in causative SNPs among the SNPs with a P-value below 0.01.

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