Age-related Hearing Loss or Presbycusis

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2010 May 14

PMID 20464410

Citations 107

Authors

Qi Huang

Jianguo Tang

Affiliations

Soon will be listed here.

Abstract

Aging is a natural consequence of a society developing process. Although many adults retain good hearing as they aging, hearing loss related with age-presbycusis which can vary in severity from mild to substantial is common among elderly persons. There are a number of pathophysiological processes underlying age-related changes in the auditory system as well as in the central nervous systems. Many studies have been dedicated to the illustration of risk factors accumulating presbycusis such as heritability, environment factors, medical conditions, free radical (reactive oxygen species, ROS) and damage of mitochondrial DNA. Left untreated, presbycusis can not only lead sufferers to reduced quality of life, isolation, dependence and frustration, but also affect the healthy people around. These can be partly corrected using hearing aids, but it is not enough, more and more strategies of treatment based on the findings associating with presbycusis should be added rather than using single hearing aids. We review here the pathophysiology; heritability, susceptibility genes and other risk factors including environmental, medical, especially free radical (ROS) and damage of mitochondrial DNA; and some strategies of treatment, as well as promising rehabilitations associating with presbycusis.

Citing Articles

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References

Le T, Keithley E . Effects of antioxidants on the aging inner ear. Hear Res. 2006; 226(1-2):194-202. DOI: 10.1016/j.heares.2006.04.003. View

Van Laer L, Eyken E, Fransen E, Huyghe J, Topsakal V, Hendrickx J . The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment. Hum Mol Genet. 2007; 17(2):159-69. DOI: 10.1093/hmg/ddm292. View

Mahncke H, Connor B, Appelman J, Ahsanuddin O, Hardy J, Wood R . Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A. 2006; 103(33):12523-8. PMC: 1526649. DOI: 10.1073/pnas.0605194103. View

Li H, Liu H, Heller S . Pluripotent stem cells from the adult mouse inner ear. Nat Med. 2003; 9(10):1293-9. DOI: 10.1038/nm925. View

Danielidis V, Tsimpiris N, Balatsouras D, Polychronidis A, Perente S, Papadopoulos N . Short-term pathophysiologic changes and histopathologic findings of the auditory pathway after closed head injury, using a rabbit model. Audiol Neurootol. 2007; 12(3):145-54. DOI: 10.1159/000099016. View

Diniz T, Guida H . Hearing loss in patients with diabetes mellitus. Braz J Otorhinolaryngol. 2009; 75(4):573-8. PMC: 9446016. DOI: 10.1016/s1808-8694(15)30498-5. View

Gates G, Mills J . Presbycusis. Lancet. 2005; 366(9491):1111-20. DOI: 10.1016/S0140-6736(05)67423-5. View

Nomura K, Nakao M, Morimoto T . Effect of smoking on hearing loss: quality assessment and meta-analysis. Prev Med. 2004; 40(2):138-44. DOI: 10.1016/j.ypmed.2004.05.011. View

Izumikawa M, Minoda R, Kawamoto K, Abrashkin K, Swiderski D, Dolan D . Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nat Med. 2005; 11(3):271-6. DOI: 10.1038/nm1193. View

10.

Matsui J, Haque A, Huss D, Messana E, Alosi J, Roberson D . Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci. 2003; 23(14):6111-22. PMC: 6740338. View

11.

Miquel J . Can antioxidant diet supplementation protect against age-related mitochondrial damage?. Ann N Y Acad Sci. 2002; 959:508-16. DOI: 10.1111/j.1749-6632.2002.tb02120.x. View

12.

Kazmierczak P, Sakaguchi H, Tokita J, Wilson-Kubalek E, Milligan R, Muller U . Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells. Nature. 2007; 449(7158):87-91. DOI: 10.1038/nature06091. View

13.

Chen P, Zindy F, Abdala C, Liu F, Li X, Roussel M . Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol. 2003; 5(5):422-6. DOI: 10.1038/ncb976. View

14.

Van Eyken E, Van Laer L, Fransen E, Topsakal V, Lemkens N, Laureys W . KCNQ4: a gene for age-related hearing impairment?. Hum Mutat. 2006; 27(10):1007-16. DOI: 10.1002/humu.20375. View

15.

Lowenheim H, Furness D, Kil J, Zinn C, Gultig K, Fero M . Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proc Natl Acad Sci U S A. 1999; 96(7):4084-8. PMC: 22424. DOI: 10.1073/pnas.96.7.4084. View

16.

Dai P, Yang W, Jiang S, Gu R, Yuan H, Han D . Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis. Acta Otolaryngol. 2004; 124(2):130-6. DOI: 10.1080/00016480410016586. View

17.

Brant L, Fozard J . Age changes in pure-tone hearing thresholds in a longitudinal study of normal human aging. J Acoust Soc Am. 1990; 88(2):813-20. DOI: 10.1121/1.399731. View

18.

Russo N, Nicol T, Zecker S, Hayes E, Kraus N . Auditory training improves neural timing in the human brainstem. Behav Brain Res. 2004; 156(1):95-103. DOI: 10.1016/j.bbr.2004.05.012. View

19.

Johnson K, Zheng Q, Erway L . A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice. Genomics. 2000; 70(2):171-80. DOI: 10.1006/geno.2000.6377. View

20.

Pichora-Fuller M, Schneider B, Benson N, Hamstra S, Storzer E . Effect of age on detection of gaps in speech and nonspeech markers varying in duration and spectral symmetry. J Acoust Soc Am. 2006; 119(2):1143-55. DOI: 10.1121/1.2149837. View