Oxidative Stress and Mitochondrial Dysfunction Across Broad-ranging Pathologies: Toward Mitochondria-targeted Clinical Strategies

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2014 May 31

PMID 24876913

Citations 65

Authors

Giovanni Pagano

Annarita Aiello Talamanca

Giuseppe Castello

Mario D Cordero

Marco dIschia

Maria Nicola Gadaleta

Federico V Pallardo

Sandra Petrovic

Luca Tiano

Adriana Zatterale

Affiliations

Soon will be listed here.

Abstract

Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.

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References

Ting A, Kah Mun Low G, Gopalakrishnan K, Hande M . Telomere attrition and genomic instability in xeroderma pigmentosum type-b deficient fibroblasts under oxidative stress. J Cell Mol Med. 2009; 14(1-2):403-16. PMC: 3837611. DOI: 10.1111/j.1582-4934.2009.00945.x. View

Rezvani H, Rossignol R, Ali N, Benard G, Tang X, Yang H . XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species. Biochim Biophys Acta. 2010; 1807(6):609-19. PMC: 3086958. DOI: 10.1016/j.bbabio.2010.12.006. View

Calabrese V, Cornelius C, Leso V, Trovato-Salinaro A, Ventimiglia B, Cavallaro M . Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes. Biochim Biophys Acta. 2011; 1822(5):729-36. DOI: 10.1016/j.bbadis.2011.12.003. View

Nur E, Brandjes D, Schnog J, Otten H, Fijnvandraat K, Schalkwijk C . Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients. Br J Haematol. 2010; 151(1):62-9. DOI: 10.1111/j.1365-2141.2010.08320.x. View

Zhang Y, Zhang L, Sun D, Li Z, Wang L, Liu P . Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract. Mol Vis. 2011; 17:2325-32. PMC: 3171498. View

Xia X, Werner D, Popanda O, Thielmann H . Expression of mitochondrial genes and DNA-repair-related nuclear genes is altered in xeroderma pigmentosum fibroblasts. J Cancer Res Clin Oncol. 1994; 120(8):454-64. DOI: 10.1007/BF01191798. View

Sohal R, Brunk U . Mitochondrial production of pro-oxidants and cellular senescence. Mutat Res. 1992; 275(3-6):295-304. DOI: 10.1016/0921-8734(92)90033-l. View

Piccolo G, Banfi P, Azan G, Rizzuto R, Bisson R, Sandona D . Biological markers of oxidative stress in mitochondrial myopathies with progressive external ophthalmoplegia. J Neurol Sci. 1991; 105(1):57-60. DOI: 10.1016/0022-510x(91)90118-q. View

Naoi M, Maruyama W, Shamoto-Nagai M, Yi H, Akao Y, Tanaka M . Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders. Mol Neurobiol. 2005; 31(1-3):81-93. DOI: 10.1385/MN:31:1-3:081. View

10.

Niu H, Yang C, Jiang G, Xu T, Cao Y, Zhao J . Cancer stroma proteome expression profile of superficial bladder transitional cell carcinoma and biomarker discovery. J Cancer Res Clin Oncol. 2011; 137(8):1273-82. DOI: 10.1007/s00432-011-0995-z. View

11.

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

12.

Wolyniec E, Karpinska J, Losiewska S, Turkowicz M, Klimczuk J, Kojlo A . Determination of lipoic acid by flow-injection and high-performance liquid chromatography with chemiluminescence detection. Talanta. 2012; 96:223-9. DOI: 10.1016/j.talanta.2012.02.064. View

13.

Croteau D, Rossi M, Canugovi C, Tian J, Sykora P, Ramamoorthy M . RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Aging Cell. 2012; 11(3):456-66. PMC: 3350572. DOI: 10.1111/j.1474-9726.2012.00803.x. View

14.

Hardas S, Sultana R, Clark A, Beckett T, Szweda L, Murphy M . Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biol. 2013; 1:80-5. PMC: 3757677. DOI: 10.1016/j.redox.2013.01.002. View

15.

Li Z, Shen J, Chen Y, Pan J, Zeng H, Fang H . Mitochondrial genome sequencing of chondrocytes in osteoarthritis by human mitochondria RT2 Profiler™ PCR array. Mol Med Rep. 2012; 6(1):39-44. DOI: 10.3892/mmr.2012.863. View

16.

Carelli V, La Morgia C, Valentino M, Rizzo G, Carbonelli M, De Negri A . Idebenone treatment in Leber's hereditary optic neuropathy. Brain. 2011; 134(Pt 9):e188. DOI: 10.1093/brain/awr180. View

17.

Miller E, Walczak A, Saluk J, Ponczek M, Majsterek I . Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis. Clin Biochem. 2011; 45(1-2):26-30. DOI: 10.1016/j.clinbiochem.2011.09.021. View

18.

DiMauro S, Schon E, Carelli V, Hirano M . The clinical maze of mitochondrial neurology. Nat Rev Neurol. 2013; 9(8):429-44. PMC: 3959773. DOI: 10.1038/nrneurol.2013.126. View

19.

Suzuki Y, Imai K, Takai K, Hanai T, Hayashi H, Naiki T . Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test. J Cancer Res Clin Oncol. 2013; 139(5):845-52. DOI: 10.1007/s00432-013-1389-1. View

20.

Shah D, Wanchu A, Bhatnagar A . Interaction between oxidative stress and chemokines: possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis. Immunobiology. 2011; 216(9):1010-7. DOI: 10.1016/j.imbio.2011.04.001. View