Oxidative Modification of Patient's Plasma Proteins and Its Role in Pathogenesis of Multiple Sclerosis

Overview

Journal Clin Biochem

Specialty Biochemistry

Date 2011 Oct 25

PMID 22019955

Citations 41

Authors

Elzbieta Miller

Anna Walczak

Joanna Saluk

Michal B Ponczek

Ireneusz Majsterek

Affiliations

Soon will be listed here.

Abstract

Background: Oxidative stress plays an important role in multiple sclerosis (MS).

Objective And Methods: The present study was designed to evaluate the modifications of plasma proteins by estimation markers of oxidative/nitrosative stress: carbonyl groups and 3-nitrotyrosines (3-NT) levels in relapsing-remitting (RR) (n=10) and secondary progressive (SP) (n=10) clinical course of multiple sclerosis. Moreover, we estimated the level of uric acid (UA) in plasma of MS patients.

Results: Compared to controls (n=10), the levels of carbonyl groups in plasma proteins were elevated (P<0.0001) as well in RRMS as in SPMS. The highest concentration of 3-NT was observed in plasma proteins obtained from SPMS patients (P<0.0005). The level of uric acid in plasma was significantly lower in RRMS (P<0.0001) than SPMS.

Conclusion: This is the first report which presented differences between SPMS and RRMS patients in 3-NT and protein carbonyl groups in plasma proteins.

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