Effect of Fat on Serum 25-hydroxyvitamin D Levels After a Single Oral Dose of Vitamin D in Young Healthy Adults: a Double-blind Randomized Placebo-controlled Study

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2014 May 24

PMID 24853643

Citations 7

Authors

Fabiana Viegas Raimundo

Maria Augusta Britto Lang

Luciano Scopel

Natalia Aydos Marcondes

Mirna Griselda Anocibar Araujo

Gustavo Adolpho Moreira Faulhaber

Tania Weber Furlanetto

Affiliations

Soon will be listed here.

Abstract

Purpose: This double-blind placebo-controlled trial evaluated serum 25-hydroxyvitamin D [25(OH)D] levels after the oral intake of a single dose of cholecalciferol during one of the three meals, containing different amounts of fat or placebo.

Methods And Results: Sixty-four healthy medical residents or students of a university hospital in Porto Alegre, latitude 30° S, Brazil, were divided into four groups. Three groups received a single 50,000 IU oral dose of cholecalciferol during a meal containing 0 g (Group 1), 15 g (Group 2) or 30 g (Group 3) of fat, and one group received placebo (Group 4), according to randomization. Serum 25(OH)D, parathyroid hormone, total calcium, albumin, magnesium, and creatinine levels, and urinary calcium, magnesium, and creatinine levels were measured at baseline and after 14 days. Baseline mean serum 25(OH)D levels were low in all groups. Vitamin D given during breakfast increased the mean change of serum 25(OH)D levels, when compared to placebo. Furthermore, the intake of fat with vitamin D increased the mean change of serum 25(OH)D levels.

Conclusion: A single oral dose of vitamin D given with food increased mean serum 25(OH)D levels, after 2 weeks, and the mean increase was larger, when the meal had at least 15 g of fat. These findings can have important implications to oral vitamin D supplementation.

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References

Biancuzzo R, Young A, Bibuld D, Cai M, Winter M, Klein E . Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. 2010; 91(6):1621-6. PMC: 2869510. DOI: 10.3945/ajcn.2009.27972. View

Reboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier J . Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol Nutr Food Res. 2011; 55(5):691-702. DOI: 10.1002/mnfr.201000553. View

Ilahi M, Armas L, Heaney R . Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr. 2008; 87(3):688-91. DOI: 10.1093/ajcn/87.3.688. View

Yin A, Alfadhli E, Htun M, Dudley R, Faulkner S, Hull L . Dietary fat modulates the testosterone pharmacokinetics of a new self-emulsifying formulation of oral testosterone undecanoate in hypogonadal men. J Androl. 2012; 33(6):1282-90. PMC: 4170073. DOI: 10.2164/jandrol.112.017020. View

Dawson-Hughes B, Harris S, Palermo N, Ceglia L, Rasmussen H . Meal conditions affect the absorption of supplemental vitamin D3 but not the plasma 25-hydroxyvitamin D response to supplementation. J Bone Miner Res. 2013; 28(8):1778-83. DOI: 10.1002/jbmr.1896. View

Zittermann A, Ernst J, Gummert J, Borgermann J . Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review. Eur J Nutr. 2013; 53(2):367-74. DOI: 10.1007/s00394-013-0634-3. View

Schnabel P, Bagchus W, Lass H, Thomsen T, Geurts T . The effect of food composition on serum testosterone levels after oral administration of Andriol Testocaps. Clin Endocrinol (Oxf). 2007; 66(4):579-85. PMC: 1859980. DOI: 10.1111/j.1365-2265.2007.02781.x. View

Raimundo F, Faulhaber G, Menegatti P, Marques L, Furlanetto T . Effect of High- versus Low-Fat Meal on Serum 25-Hydroxyvitamin D Levels after a Single Oral Dose of Vitamin D: A Single-Blind, Parallel, Randomized Trial. Int J Endocrinol. 2011; 2011:809069. PMC: 3235461. DOI: 10.1155/2011/809069. View

Luporini Saraiva G, Cendoroglo M, Ramos L, Araujo L, Vieira J, Kunii I . Influence of ultraviolet radiation on the production of 25 hydroxyvitamin D in the elderly population in the city of São Paulo (23 degrees 34'S), Brazil. Osteoporos Int. 2005; 16(12):1649-54. DOI: 10.1007/s00198-005-1895-3. View

10.

Mulligan G, Licata A . Taking vitamin D with the largest meal improves absorption and results in higher serum levels of 25-hydroxyvitamin D. J Bone Miner Res. 2010; 25(4):928-30. DOI: 10.1002/jbmr.67. View

11.

Wagner D, Sidhom G, Whiting S, Rousseau D, Vieth R . The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults. J Nutr. 2008; 138(7):1365-71. DOI: 10.1093/jn/138.7.1365. View

12.

Niramitmahapanya S, Harris S, Dawson-Hughes B . Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation. J Clin Endocrinol Metab. 2011; 96(10):3170-4. PMC: 3200243. DOI: 10.1210/jc.2011-1518. View

13.

Roberts W . Skin type classification systems old and new. Dermatol Clin. 2009; 27(4):529-33, viii. DOI: 10.1016/j.det.2009.08.006. View

14.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

15.

Nelson M, Blum J, Hollis B, Rosen C, Sullivan S . Supplements of 20 microg/d cholecalciferol optimized serum 25-hydroxyvitamin D concentrations in 80% of premenopausal women in winter. J Nutr. 2009; 139(3):540-6. DOI: 10.3945/jn.108.096180. View

16.

Ryan J, Anderson P, Turner A, Morris H . Vitamin D activities and metabolic bone disease. Clin Chim Acta. 2013; 425:148-52. DOI: 10.1016/j.cca.2013.07.024. View

17.

Iqbal J, Hussain M . Intestinal lipid absorption. Am J Physiol Endocrinol Metab. 2009; 296(6):E1183-94. PMC: 2692399. DOI: 10.1152/ajpendo.90899.2008. View

18.

Zhao L, Zhou Y, Bu F, Travers-Gustafson D, Ye A, Xu X . Factors predicting vitamin D response variation in non-Hispanic white postmenopausal women. J Clin Endocrinol Metab. 2012; 97(8):2699-705. PMC: 3410260. DOI: 10.1210/jc.2011-3401. View

19.

Heaney R, Recker R, Grote J, Horst R, Armas L . Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab. 2010; 96(3):E447-52. DOI: 10.1210/jc.2010-2230. View

20.

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View