PHF8 and REST/NRSF Co-occupy Gene Promoters to Regulate Proximal Gene Expression

Overview

Journal Sci Rep

Specialty Science

Date 2014 May 24

PMID 24852203

Citations 12

Authors

Juan Wang

Xueqiu Lin

Su Wang

Chenfei Wang

Qixuan Wang

Xikun Duan

Peng Lu

Qian Wang

Chengyang Wang

X Shirley Liu

Jinyan Huang

Affiliations

Soon will be listed here.

Abstract

Chromatin regulators play an important role in the development of human diseases. In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently. PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei. Mutations of PHF8 are associated with X-linked mental retardation. It usually functions as a transcriptional co-activator by associating with H3K4me3 and RNA polymerase II. We found that PHF8 may associate with another regulator, REST/NRSF, predominately at promoter regions via studying several published PHF8 chromatin immunoprecipitation-sequencing (ChIP-Seq) datasets. Our analysis suggested that PHF8 not only activates but may also repress gene expression.

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