» Articles » PMID: 21423274

Readers of Histone Modifications

Overview
Journal Cell Res
Specialty Cell Biology
Date 2011 Mar 23
PMID 21423274
Citations 272
Authors
Affiliations
Soon will be listed here.
Abstract

Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.

Citing Articles

Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in personalised medicine.

Rajendran P, Prasad M, Ali E, Sekar R, Alzahrani A, Karobari M J Cancer. 2025; 16(5):1575-1590.

PMID: 39991574 PMC: 11843246. DOI: 10.7150/jca.103243.


ATAC and SAGA histone acetyltransferase modules facilitate transcription factor binding to nucleosomes independent of their acetylation activity.

Chesnutt K, Yayli G, Toelzer C, Damilot M, Cox K, Gautam G Nucleic Acids Res. 2024; 53(1.

PMID: 39656677 PMC: 11724297. DOI: 10.1093/nar/gkae1120.


A Method for Characterizing Protein-Histone Peptide Interactions In Vitro.

Jourdain C, Eichstadt B, Schubert D Methods Mol Biol. 2024; 2873:167-184.

PMID: 39576602 DOI: 10.1007/978-1-0716-4228-3_10.


The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy.

Oleksiewicz U, Kuciak M, Jaworska A, Adamczak D, Bisok A, Mierzejewska J Int J Mol Sci. 2024; 25(21).

PMID: 39519018 PMC: 11546771. DOI: 10.3390/ijms252111466.


Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma.

Seneviratne J, Ravindrarajah D, Carter D, Zhai V, Lalwani A, Krishan S Cancer Med. 2024; 13(21):e70082.

PMID: 39501501 PMC: 11538032. DOI: 10.1002/cam4.70082.


References
1.
Geng F, Tansey W . Polyubiquitylation of histone H2B. Mol Biol Cell. 2008; 19(9):3616-24. PMC: 2526708. DOI: 10.1091/mbc.e08-01-0050. View

2.
Walter W, Clynes D, Tang Y, Marmorstein R, Mellor J, Berger S . 14-3-3 interaction with histone H3 involves a dual modification pattern of phosphoacetylation. Mol Cell Biol. 2008; 28(8):2840-9. PMC: 2293105. DOI: 10.1128/MCB.01457-07. View

3.
Gelbart M, Bachman N, Delrow J, Boeke J, Tsukiyama T . Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev. 2005; 19(8):942-54. PMC: 1080133. DOI: 10.1101/gad.1298905. View

4.
Vogelauer M, Rubbi L, Lucas I, Brewer B, Grunstein M . Histone acetylation regulates the time of replication origin firing. Mol Cell. 2002; 10(5):1223-33. DOI: 10.1016/s1097-2765(02)00702-5. View

5.
Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N . Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature. 2010; 464(7289):792-6. DOI: 10.1038/nature08839. View