Next Generation Platforms for High-throughput Biodosimetry

Overview

Journal Radiat Prot Dosimetry

Publisher Oxford University Press

Date 2014 May 20

PMID 24837249

Citations 15

Authors

Mikhail Repin

Helen C Turner

Guy Garty

David J Brenner

Affiliations

Soon will be listed here.

Abstract

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems.

Citing Articles

Development of high-throughput systems for biodosimetry.

Wilkins R, Beaton-Green L Radiat Prot Dosimetry. 2023; 199(14):1477-1484.

PMID: 37721060 PMC: 10720693. DOI: 10.1093/rpd/ncad060.

Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.

Ghandhi S, Morton S, Shuryak I, Lee Y, Soni R, Perrier J BMC Genomics. 2023; 24(1):139.

PMID: 36944971 PMC: 10031949. DOI: 10.1186/s12864-023-09230-7.

The use of a centrifuge-free RABiT-II system for high-throughput micronucleus analysis.

Repin M, Pampou S, Brenner D, Garty G J Radiat Res. 2019; 61(1):68-72.

PMID: 31825079 PMC: 6976732. DOI: 10.1093/jrr/rrz074.

RABiT-II-DCA: A Fully-automated Dicentric Chromosome Assay in Multiwell Plates.

Royba E, Repin M, Pampou S, Karan C, Brenner D, Garty G Radiat Res. 2019; 192(3):311-323.

PMID: 31295087 PMC: 8567107. DOI: 10.1667/RR15266.1.

Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay.

Wang Q, Rodrigues M, Repin M, Pampou S, Beaton-Green L, Perrier J Radiat Res. 2019; 191(4):342-351.

PMID: 30779694 PMC: 6483078. DOI: 10.1667/RR15243.1.

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