Towards Precision Prevention: Technologies for Identifying Healthy Individuals with High Risk of Disease

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 2017 May 2

PMID 28458064

Citations 16

Authors

Zachary D Nagel

Bevin P Engelward

David J Brenner

Thomas J Begley

Robert W Sobol

Jason H Bielas

Peter J Stambrook

Qingyi Wei

Jennifer J Hu

Mary Beth Terry

Caroline Dilworth

Kimberly A McAllister

Les Reinlib

Leroy Worth

Daniel T Shaughnessy

Affiliations

Soon will be listed here.

Abstract

The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision medicine and personalized prevention. In this commentary, we highlight recently developed enabling technologies in the field of DNA damage, DNA repair, and mutagenesis. We propose that omics approaches and functional assays can be integrated into population studies that fuse basic, translational and clinical research with commercial expertise in order to accelerate personalized prevention and treatment of cancer and other diseases linked to aberrant responses to DNA damage. This collaborative approach is generally applicable to efforts to develop data-driven, individualized prevention and treatment strategies for other diseases. We also recommend strategies for maximizing the use of biological samples for epidemiological studies, and for applying emerging technologies to clinical applications.

Citing Articles

Cosmic Ionizing Radiation: A DNA Damaging Agent That May Underly Excess Cancer in Flight Crews.

Toprani S, Scheibler C, Mordukhovich I, McNeely E, Nagel Z Int J Mol Sci. 2024; 25(14).

PMID: 39062911 PMC: 11277465. DOI: 10.3390/ijms25147670.

Annual space weather fluctuations and telomere length dynamics in a longitudinal cohort of older men: the Normative Aging Study.

Zhai T, Zilli Vieira C, Vokonas P, Baccarelli A, Nagel Z, Schwartz J J Expo Sci Environ Epidemiol. 2023; 34(6):1072-1080.

PMID: 38066331 DOI: 10.1038/s41370-023-00616-z.

Simultaneous Short- and Long-Patch Base Excision Repair (BER) Assay in Live Mammalian Cells.

Roy R Methods Mol Biol. 2023; 2701():3-19.

PMID: 37574472 DOI: 10.1007/978-1-0716-3373-1_1.

Co-creation and engagement in a DNA integrity cohort study.

Parker L, Bonner C, Sobol R, Arrieta M J Clin Transl Sci. 2023; 7(1):e122.

PMID: 37313377 PMC: 10260344. DOI: 10.1017/cts.2023.556.

Human Variation in DNA Repair, Immune Function, and Cancer Risk.

Cheong A, Nagel Z Front Immunol. 2022; 13:899574.

PMID: 35935942 PMC: 9354717. DOI: 10.3389/fimmu.2022.899574.

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