Down Regulation of MiR-143 is Related with Tumor Size, Lymph Node Metastasis and HPV16 Infection in Cervical Squamous Cancer

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2014 Apr 30

PMID 24774218

Citations 22

Authors

Yanxia Chen

Cailing Ma

Wei Zhang

Zhifang Chen

Li Ma

Affiliations

Soon will be listed here.

Abstract

Objective: This study is to investigate the role of miR-143 expression in cervical squamous cell carcinoma (SCC).

Methods: The expression level of miR-143 was examined by quantitative real-time PCR. Human papillomavirus (HPV) genotype was detected by HPV genotype detection kit. The expression level of bcl-2 was detected by immunohistochemistry.

Results: The positive rate of HPV was 78% in the patients of cervical SCC. The most prevalent genotype was HPV16, with a positive rate of 42%. The expression level of miR-143 was significantly lower in the cervical SCC tissues than that in the normal cervical tissues (Z=-2.180, P=0.029). Down-regulated miR-143 expression was associated with tumor size, lymph node metastasis and HPV16 infection in cervical cancer patients. No significant associations were found between the expression levels of miR-143 and age, clinical stage, differentiation or lymph vascular space invasion. And, in cervical SCC patients after treatment with Taxol chemotherapy, the expression level of miR-143 was higher and the positive expression of bcl-2 protein was lower. However, the differences in expression changes of miR-143 and bcl-2 were not statistically significant (miR-143, Z=-0.763, P=0.446; bcl-2 protein, χ2=2.277, P=0.131).

Conclusion: Down-regulated miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical SCC, but miR-143 does not participate in the Taxol sensitivity response.

Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1401279451112150.

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Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review.

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Causin R, Freitas A, Hidalgo Filho C, Dos Reis R, Reis R, Marques M Cells. 2021; 10(3).

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