The Role of MiRNAs in Human Papilloma Virus (HPV)-associated Cancers: Bridging Between HPV-related Head and Neck Cancer and Cervical Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2012 Apr 5

PMID 22472886

Citations 106

Authors

C B Lajer

E Garnaes

L Friis-Hansen

B Norrild

M H Therkildsen

M Glud

M Rossing

H Lajer

D Svane

L Skotte

L Specht

C Buchwald

F C Nielsen

Affiliations

Soon will be listed here.

Abstract

Background: Although the role of human papilloma virus (HPV) in cervical squamous cell carcinoma (CSCC) is well established, the role in head and neck SCC (HNSCC) is less clear. MicroRNAs (miRNAs) have a role in the cancer development, and HPV status may affect the miRNA expression pattern in HNSCC. To explore the influence of HPV in HNSCC, we made a comparative miRNA profile of HPV-positive (HPV+) and HPV-negative (HPV-) HNSCC against CSCC.

Methods: Fresh frozen and laser microdissected-paraffin-embedded samples obtained from patients with HPV+/HPV- HNSCC, CSCC and controls were used for microarray analysis. Differentially expressed miRNAs in the HPV+ and HPV- HNSCC samples were compared with the differentially expressed miRNAs in the CSCC samples.

Results: Human papilloma virus positive (+) HNSCC had a distinct miRNA profile compared with HPV- HNSCC. Significantly more similarity was seen between HPV+ HNSCC and CSCC than HPV- and CSCC. A set of HPV core miRNAs were identified. Of these especially the miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis.

Conclusion: This study adds new knowledge to the known pathogenic pathways of HPV and substantiates the oncogenic role of HPV in subsets of HNSCCs.

Citing Articles

New evidence for miRNA testing in head and neck squamous cell cancer patients.

Galindo Torres B, Alcaraz Ortega R, Saiz Lopez P, Adiego Leza M, Moradillo Renuncio M, Garcia Giron C Clin Transl Oncol. 2025; .

PMID: 39913046 DOI: 10.1007/s12094-025-03854-9.

The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer.

Balaraman A, Afzal M, Moglad E, Babu M, Priya G, Bansal P Biogerontology. 2025; 26(2):50.

PMID: 39907830 DOI: 10.1007/s10522-025-10194-2.

miRNAs Dysregulated in Human Papillomavirus-Associated Benign Prostatic Lesions and Prostate Cancer.

Salgado-Hernandez S, Martinez-Retamoza L, Ocadiz-Delgado R, Perez-Mora S, Cedeno-Arboleda G, Gomez-Garcia M Cancers (Basel). 2025; 17(1.

PMID: 39796656 PMC: 11718816. DOI: 10.3390/cancers17010026.

A Review of the Interaction between miRNAs and Ebola Virus.

Kakavandi E, Yavarian J, Farzanehpour M, Shayestehpour M Int J Mol Cell Med. 2024; 13(2):210-219.

PMID: 39184819 PMC: 11344561. DOI: 10.22088/IJMCM.BUMS.13.2.210.

The Role of Biomarkers in HPV-Positive Head and Neck Squamous Cell Carcinoma: Towards Precision Medicine.

Krsek A, Baticic L, Sotosek V, Braut T Diagnostics (Basel). 2024; 14(13).

PMID: 39001338 PMC: 11241541. DOI: 10.3390/diagnostics14131448.

References

Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L . miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res. 2009; 69(13):5553-9. DOI: 10.1158/0008-5472.CAN-08-4277. View

Landais S, Landry S, Legault P, Rassart E . Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res. 2007; 67(12):5699-707. DOI: 10.1158/0008-5472.CAN-06-4478. View

Hafkamp H, Manni J, Haesevoets A, Voogd A, Schepers M, Bot F . Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer. 2008; 122(12):2656-64. DOI: 10.1002/ijc.23458. View

Michael M, O Connor S, van Holst Pellekaan N, Young G, James R . Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res. 2003; 1(12):882-91. View

Pyeon D, Newton M, Lambert P, den Boon J, Sengupta S, Marsit C . Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res. 2007; 67(10):4605-19. PMC: 2858285. DOI: 10.1158/0008-5472.CAN-06-3619. View

Pereira P, Marques J, Soares A, Carreto L, Santos M . MicroRNA expression variability in human cervical tissues. PLoS One. 2010; 5(7):e11780. PMC: 2909898. DOI: 10.1371/journal.pone.0011780. View

Rosenfeld N, Aharonov R, Meiri E, Rosenwald S, Spector Y, Zepeniuk M . MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 2008; 26(4):462-9. DOI: 10.1038/nbt1392. View

Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T . Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci. 2007; 98(12):1914-20. PMC: 11158757. DOI: 10.1111/j.1349-7006.2007.00618.x. View

Wald A, Hoskins E, Wells S, Ferris R, Khan S . Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. Head Neck. 2010; 33(4):504-12. PMC: 3080748. DOI: 10.1002/hed.21475. View

10.

Walboomers J, Jacobs M, Manos M, Bosch F, Kummer J, Shah K . Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999; 189(1):12-9. DOI: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F. View

11.

Boominathan L . The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One. 2010; 5(5):e10615. PMC: 2868896. DOI: 10.1371/journal.pone.0010615. View

12.

Nasman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G . Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?. Int J Cancer. 2009; 125(2):362-6. DOI: 10.1002/ijc.24339. View

13.

Warnakulasuriya S . Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2008; 45(4-5):309-16. DOI: 10.1016/j.oraloncology.2008.06.002. View

14.

Rosenwald S, Gilad S, Benjamin S, Lebanony D, Dromi N, Faerman A . Validation of a microRNA-based qRT-PCR test for accurate identification of tumor tissue origin. Mod Pathol. 2010; 23(6):814-23. DOI: 10.1038/modpathol.2010.57. View

15.

Wise-Draper T, Wells S . Papillomavirus E6 and E7 proteins and their cellular targets. Front Biosci. 2007; 13:1003-17. DOI: 10.2741/2739. View

16.

Akao Y, Nakagawa Y, Naoe T . MicroRNA-143 and -145 in colon cancer. DNA Cell Biol. 2007; 26(5):311-20. DOI: 10.1089/dna.2006.0550. View

17.

Lajer C, Nielsen F, Friis-Hansen L, Norrild B, Borup R, Garnaes E . Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study. Br J Cancer. 2011; 104(5):830-40. PMC: 3048216. DOI: 10.1038/bjc.2011.29. View

18.

Ghittoni R, Accardi R, Hasan U, Gheit T, Sylla B, Tommasino M . The biological properties of E6 and E7 oncoproteins from human papillomaviruses. Virus Genes. 2009; 40(1):1-13. DOI: 10.1007/s11262-009-0412-8. View

19.

Zheng Z, Wang X . Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta. 2011; 1809(11-12):668-77. PMC: 3175324. DOI: 10.1016/j.bbagrm.2011.05.005. View

20.

Wang X, Tang S, Le S, Lu R, Rader J, Meyers C . Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One. 2008; 3(7):e2557. PMC: 2438475. DOI: 10.1371/journal.pone.0002557. View